fa P12: Cell Therapies for Neurological Injury تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p style="text-align: center;"><span style="color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; text-align: center; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> <p>A neurological disorder is any <a href="https://en.wikipedia.org/wiki/Disorder_(medicine)#Disorder" title="Disorder (medicine)">disorder</a> of the <a href="https://en.wikipedia.org/wiki/Nervous_system" title="Nervous system">nervous system</a> is usually due to cell loss. The ultimate goal of CNS therapy is to replace lost cells and tissue. There is no neuroprotective, pharmacological and effective treatment available that restores the injury-induced loss of function. Recent studies suggest that identification of adult neural stem/progenitor cells indwelling in the neurogenic regions in the adult mammalian brain and spinal cord may play regenerative and reparative roles in response to CNS injuries. Therefore, cell transplantation is a potential strategy to repair and regenerate the injured brain and spinal cord. Different types of stem cells vary in their ability to help restore function, and an ideal treatment protocol remains unclear pending further clinical research. Stem cells derived from adult tissues such as mesenchymal progenitor cells, fetal progenitors, and post-mitotic cells have a limited potential to differentiate into specific cell types. As Brain and spinal cord injury are associated with enormous loss of multiple cell types due to primary mechanical tissue disruption.&nbsp;The choice of stem cell population used in replacement therapies after Brain and spinal cord injury might therefore be critical.</p> Neurological injury, Cell therapies, Neural stem/progenitor cells 34 34 http://shefayekhatam.ir/browse.php?a_code=A-10-24-803&slc_lang=fa&sid=1 Sara Abdolahi Sara Abdolahi abdolahisara65@gmail.com 100319475328460011400 100319475328460011400 Yes a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Sedigheh Ghasemi Sedigheh Ghasemi 100319475328460011401 100319475328460011401 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Robabeh Jafari Robabeh Jafari 100319475328460011402 100319475328460011402 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Zeinab Najmi Zeinab Najmi 100319475328460011403 100319475328460011403 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Microbial biotechnology Group, Faculty of Basic Sciences, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Microbial biotechnology Group, Faculty of Basic Sciences, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran