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:: Volume 5, Number 2 (Spring - 2017) ::
Shefaye Khatam 2017, 5(2): 76-87 Back to browse issues page
Development of Nanoparticles for Drug Delivery to the Brain
Elham Afjeh Dana, Masoud Marivani, Bita Mehravi, Fariba Karimzadeh *, Khadijeh Ashtari
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran , Fariba_karimzade@yahoo.com
Abstract:   (492 Views)

Introduction: The central nervous system is one of the most sensitive microenvironments of the body that protected by the blood-brain barrier (BBB). BBB is a highly complex structure that tightly controls exchange of a range of small and large molecules, which protects the brain from damages and diseases. The promising feature of BBB in molecular movement from bloodstream into the nervous tissue affects delivery of several drugs to the brain. In order to increase drugs permeability through BBB various strategies have been developed. Among them, nanotechnology has provided effective methods for researchers in the field of drug delivery to the brain. Conclusion: In this paper, the structure and physiological properties of BBB as well as new strategies for drug delivery to the brain by using nanoparticles are discussed. 

Keywords: Nanoparticles, Brain, Central Nervous System
Full-Text [PDF 1186 kb]   (374 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience



DOI: 10.18869/acadpub.shefa.5.2.76


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Afjeh Dana E, Marivani M, Mehravi B, Karimzadeh F, Ashtari K. Development of Nanoparticles for Drug Delivery to the Brain. Shefaye Khatam. 2017; 5 (2) :76-87
URL: http://shefayekhatam.ir/article-1-1364-en.html
Volume 5, Number 2 (Spring - 2017) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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