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دوره 6 شماره 3 صفحات 52-68 برگشت به فهرست نسخه ها
سلول درمانی: یک راهکار درمانی برای مالتیپل اسکلروز
محمدرضا خجسته، سید علی شریعت رضوی، آیدا جوادزاده، علی گرجی، سجاد سحاب نگاه*
الف. گروه علوم اعصاب، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران. ب. مرکز تحقیقات علوم اعصاب شفا، بیمارستان خاتم‌الانبیا، تهران، ایران ، sahabnegahs@mums.ac.ir
چکیده:   (967 مشاهده)
مقدمه: مالتیپل اسکلروز یک بیماری خود ایمنی سیستم عصبی مرکزی است که موجب دمیلینه شدن و آسیب به آکسون می شود. روش‌های درمانی متفاوتی از جمله: تجویز اینترفرون β، گلاتیرامراستات، ناتالیزوماب فینگولیمود و سایر عوامل تعدیل‌کننده سیستم ایمنی برای مالتیپل اسکلروز وجود دارد. در حال حاضر درمان پذیرفته شده برای مالتیپل اسکلروز در درجه اول کاهش التهاب سیستم عصبی مرکزی است. به طور قابل توجهی چالش حل نشده در زمینه مالتیپل اسکلروز پیشروی به سوی روش درمانی محافظت از نورون‌ها و میلین‌سازی مجدد برای درمان بیماران مبتلا به مالتیپل اسکلروز است. راهبردهای درمانی برای جلوگیری از آسیب بافتی و یا افزایش میلین‌سازی مجدد و بازسازی آکسونی به طور جدی مورد نیاز است. نتیجه‌گیری: اخیراً کاربرد سلول‌ درمانی برای درمان مالتیپل اسکلروز امید زیادی را جهت درمان بیماران مبتلا به مالتیپل اسکلروز ایجاد کرده است. چندین مطالعه نشان داده است که سلول‌ درمانی تأثیرات ضد التهابی و تعدیل‌کننده ایمنی در بافت مغز دارد. در این مطالعه مروری ما ویژگی های انواع سلول‌های بنیادی و نقش آن‌ها در درمان مالتیپل اسکلروز را توضیح داده‌ایم.
واژه‌های کلیدی: مالتیپل اسکلروز، سلول‌های بنیادی، میلین‌سازی مجدد، سیستم عصبی مرکزی
متن کامل [PDF 1059 kb]   (402 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: نوروايمونولوژي
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Khojasteh M R, Shariat Razavi A, Javadzadeh A, Gorji A, Sahab Negah S. Cell Therapy: A Therapeutic Option for Multiple Sclerosis. Shefaye Khatam. 2018; 6 (3) :52-68
URL: http://shefayekhatam.ir/article-1-1742-fa.html

خجسته محمدرضا، شریعت رضوی علی، جوادزاده آیدا، گرجی علی، سحاب نگاه سجاد. سلول درمانی: یک راهکار درمانی برای مالتیپل اسکلروز. مجله علوم اعصاب شفای خاتم. 1397; 6 (3) :52-68

URL: http://shefayekhatam.ir/article-1-1742-fa.html



دوره 6، شماره 3 - ( تابستان - 1397 ) برگشت به فهرست نسخه ها
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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