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دوره 7 شماره 1 صفحات 106-118 برگشت به فهرست نسخه ها
میکروبیوتای روده: عاملی مؤثر بر مغز و رفتار انسان
سجاد باباخانی* ، فرزانه حسینی
گروه میکروبیولوژی، دانشکده علوم زیستی، واحد تهران شمال، دانشگاه آزاد اسلامی، تهران، ایران ، s_babakhani_s@yahoo.com
چکیده:   (146 مشاهده)
مقدمه: میکروارگانیسم‌هایی که به‌ صورت همزیست در روده انسان زندگی می‌کنند را میکروبیوتای روده می‌نامند. میکروبیوتای روده از باکتری‌ها، آرکی‌ها و یوکاریوت‌ها تشکیل شده است. با این وجود باکتری‌ها جمعیت غالب میکروبیوتای روده هستند. میکروبیوتای روده رابطه سودمندی با انسان‌ها دارد. 1014 میکروارگانیسم در روده‌ ساکن هستند که بسیاری از عملکردهای فیزیولوژیک بدن را تنظیم می‌کنند. علاوه بر اثر میکروبیوتا بر دستگاه گوارش، این میکروارگانیسم‌ها می‌توانند عملکرد مغز و سیستم عصبی مرکزی را تنظیم کنند. سیستم عصبی روده‌ای با توجه به خودمختار بودن و شباهت با سیستم عصبی مرکزی به‌عنوان مغز دوم شناسایی می‌شود. نتیجه‌گیری: میکروبیوتای روده عاملی تأثیرگذار بر تغییر رفتار و خلق‌وخوی است و حتی از پیشرفت بیماری‌های سیستم عصبی مانند مالتیپل اسکلروز، اوتیسم، آلزایمر، اسکیزوفرنی و پارکینسون پیشگیری می‌کند. میکروبیوتای روده از طریق سیستم عصبی روده‌ای، تولید متابولیت‌ها، تحریک سلول‌های انترواندوکراین و سیستم ایمنی، عملکرد سیستم عصبی مرکزی را تنظیم می‌کند. تغذیه نامناسب، استفاده بی‌رویه از آنتی‌بیوتیک‌ها، استرس، اضطراب و افسردگی موجب برهم خوردن تعادل (Dysbiosis) میکروبیوتای روده می‌شوند که عاملی مهم در تشدید بیماری‌های سیستم عصبی است.
واژه‌های کلیدی: رفتار، سیستم عصبی، مغز، میکروبیوتا
متن کامل [PDF 762 kb]   (92 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: نوروبيولوژي مولكولي
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Babakhani S, Hosseini F. Gut Microbiota: An Effective Factor in the Human Brain and Behavior. Shefaye Khatam. 2019; 7 (1) :106-118
URL: http://shefayekhatam.ir/article-1-1859-fa.html

باباخانی سجاد، حسینی فرزانه. میکروبیوتای روده: عاملی مؤثر بر مغز و رفتار انسان. مجله علوم اعصاب شفای خاتم. 1397; 7 (1) :106-118

URL: http://shefayekhatam.ir/article-1-1859-fa.html



دوره 7، شماره 1 - ( زمستان - 1397 ) برگشت به فهرست نسخه ها
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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