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:: Volume 8, Issue 2 (Spring 2020) ::
Shefaye Khatam 2020, 8(2): 93-106 Back to browse issues page
Stress-Induced Immune Dysfunction: Implications for Intrapersonal and Interpersonal Processes
Ali Sepehrinezhad, Javad Momeni, Ali Gorji, Sajad Sahab Negah *
a. Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran , sahabnegahs@mums.ac.ir
Abstract:   (1111 Views)
Introduction: Psychoneuroimmunology researchers have focused on experimental and clinical investigations to figure out how stressors and their negative emotions can affect the physiological alterations and impact on health. Clinical investigations show that the central nervous system interacts with the endocrine and immune systems in a bidirectional manner. Stress-induced immune dysregulation is occurred by the humoral and cellular immune responses. Furthermore, chronic stress can promote the production of proinflammatory cytokines, such as interleukin (IL)-6, which leads to an increase of a variety of chronic diseases. Conclusion: Given the impact of stress on health outcomes, it is necessary to improve our knowledge on the implicated pathways in which stress affects immune functioning, as well as the psychological factors that may impair or improve the effects of stress on immune responses. The aim of this study was to review the recent investigations on the role of stress on immune system and the psychological factors that may regulate this effect.
Keywords: Immune System, Psychoneuroimmunology, Health
Full-Text [PDF 682 kb]   (1184 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience
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Sepehrinezhad A, Momeni J, Gorji A, Sahab Negah S. Stress-Induced Immune Dysfunction: Implications for Intrapersonal and Interpersonal Processes. Shefaye Khatam. 2020; 8 (2) :93-106
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مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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