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Shefaye Khatam 2014, 2 - The Autumn Supplement of Shefaye Khatam 3 -: 49-49 Back to browse issues page
W6: Self‐Assembling Peptide Nanofiber Containing Biologic Motif Induces Neural Differentiation, Tubulin Polymerization and Neurogenesis In‐Vitro, Ex‐Vivo and In‐Vivo Studies
Shima Tavakol, Reza Saber, Elham Hoveizi, Hadi Aligholi, Jafar Ai, Mahdi Rezayat Seyed *
a. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. b. Department of Toxicology & Pharmacology, School of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran. c. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. , Rezayat@tums.ac.ir
Abstract:   (3750 Views)
Spinal cord injury (SCI) in humans remains a devastating and incurable disorder. A very important obstacle in axonal regeneration after spinal cord injury is astroglial scaring. The use of self-assembling peptide nanofiber, a hydrogel mimicking extracellular matrix, has been suggested as a scaffold for spinal cord regeneration and inhibition of astrogliosis. However, neurogenesis potential of laminim has been proved. The purpose of this study was to investigate the role of self-assembling peptide nanofiber containing long motif of laminin (SAPN-LL) in neural differentiation of human endometrial-derived stem cells (hEnSCs) in-vitro, in polymerization of tubulin isolated from sheep brain ex-vivo and assess the supportive effects of this hydrogel in an animal model of SCI. Results showed that although nanaofibers strongly differentiated hEnSC towards neuron and there were not significant differences between their neural differentiations but motor recovery results demonstrated that concentration of laminin influences motor recovery and tubulin polymerization. However, both of in-vitro and in-vivo results showed that SAPN-LL inhibited astrogenesis. Based on our results it might be concluded that, SAPN containing long motif of laminin holds great promise for spinal cord injury.
Keywords: Self-assembling Peptide Nanofiber, Long Motif of Laminin, Spinal Cord Injury, Polymerization of Tubulin
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Tavakol S, Saber R, Hoveizi E, Aligholi H, Ai J, Rezayat M. W6: Self‐Assembling Peptide Nanofiber Containing Biologic Motif Induces Neural Differentiation, Tubulin Polymerization and Neurogenesis In‐Vitro, Ex‐Vivo and In‐Vivo Studies. Shefaye Khatam. 2014; 2 (S3) :49-49
URL: http://shefayekhatam.ir/article-1-508-en.html


Volume 2 - The Autumn Supplement of Shefaye Khatam 3 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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