Globally around 38 million people die each year as a result of non communicable diseases (NCDs) in which 42% (~ 16 million) are premature deaths (below the age of 70). Nine voluntary global targets were set by World Health Organization to control above mentioned premature deaths. Iran added 4 more targets to it, including 20% reduction in the mortality rate due to road traffic injuries. The need to include road traffic injuries among the first priorities of the public health agenda has been increasingly recognized in Iran. This recognition is based on the growing evidence and awareness about the magnitude of road traffic injuries in our country. A comprehensive literature review was conducted and all related national and international reference documents were reviewed. Iranian national service framework was prepared to emphasis the role of health sector in this area containing 8 strategic objectives and 64 strategies to be achieved by 2025.