Introduction: Drug-resistant epilepsy surgery has countless biological and psychological complications. Many of these patients can be treated with epilepsy surgery. Despite numerous surgeries in Iranian medical centers, only the results of few of them are published. Materials and Methods: To assess the outcome of the surgery, a total number of forty patients who undergone operation between 2004 and 2014 in Loghman Hakim hospital are included in our retrospective study. Results: 52.5% of operated patients, who are included in first class of Engel criteria, were completely free of seizures. The second, third and fourth class of Engel criteria contain 25, 15 and 7.5 percent of the operated patients. There was no statistically significant difference in surgery outcomes based on the gender, primary seizure type, and surgery approach. Only 5% of the patients have permanent neurological complications, most commonly hemiparesis. Conclusion: The results of this study show the importance of early diagnosis and regular monitoring of epileptic patients. This significantly decreases the rate of unnecessary drug intake and increases the number of symptom-free individuals.