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Shefaye Khatam 2017, 5 - The Supplement of Shefaye Khatam 2: 5-5 Back to browse issues page
O 5: Coagulation Factors in Multiple Sclerosis may Represent Diagnostic and Therapeutic Strategies
Mokhtar Ahmadi *, Hossein Feizi, Fatemeh Shahbeigi
Islamic Azad University, Mashhad Branch, Mashhad, Iran , Mokhtarahmadi88@yahoo.com
Abstract:   (141 Views)

Multiple sclerosis (MS) is a neuroinflammatory autoimmune disease which mediated by various molecular and cellular immune components However Recent reports have shown that coagulation factors that traditionally separate from the immune system might also be involved in MS development and progression.studies on experimental autoimmune encephalomyelitis (EAE) and human MS patients reports alterations of some factors of the coagulation cascade such as fibrin, thrombin, prothrombin, factor X and FXII to confirm that coagulation factors have an important role in pathogenesis of autoimmune inflammatory disorders, recent studies report that Genetic deficiency or pharmacologic blockade of FXII significantly protected from EAE and also fibrin depletion, either genetically or using anticoagulants, significantly reduces neurolinflammation, and axonal damage in EAE. Another important study shows that increase thrombin activity is an early event and increases with progression of neuroinflammatory disease, with noted microglial activation and axonal damage. In this review we aim to evaluate elevated coagulation factors of tissue or blood as a new therapeutic strategy for the treatment of MS or other neuroinflammatoy disorders. As we described some coagulation factors such as fibrin and thrombin are significantly increased in MS and blockade of this factors in EAE improve neurolinflammation, and axonal damage so maybe using anticoagulants in Clinical trials develop treatment of MS.

Keywords: Coagulation factor, Multiple sclerosis, MS, Neuroinflammation
Full-Text [PDF 203 kb]   (57 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience



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Ahmadi M, Feizi H, Shahbeigi F. O 5: Coagulation Factors in Multiple Sclerosis may Represent Diagnostic and Therapeutic Strategies. Shefaye Khatam. 2017; 5 (S2) :5-5
URL: http://shefayekhatam.ir/article-1-1159-en.html
Volume 5 - The Supplement of Shefaye Khatam 2 Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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