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Back to browse issues page Shefaye Khatam 2017, 5 - The Supplement of Shefaye Khatam 2: 9-9
O 9: Immunomodulatory Effects of Neural Stem Cell on Multiple Sclerosis: A Systematic Review
Sanaz Sheykhian *, Sajad Sahab Negah
Islamic Azad University, Mashhad, Iran , sanaz.shaykhian@gmail.com
Abstract:   (44 Views)

Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating disorders of central nervous system (CNS). While the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. One of the approaches being proposed in EAE therapy is neural stem cells (NSCs) transplantation. Several studies have been conducted, investigating immunomodulatory effects of neural stem cells (NSCs) in order to assess their efficacy in the animal model of MS, but still controversies have remained. Our study aim was to systematically review the existing papers in the field of immunomodulatory Effects of Neural Stem Cell on Multiple Sclerosis. The systematic review was conducted according to the preferred reporting items for systematic reviews guidelines. We searched PubMed and Scopus databases based on the relevant medical subject headings (MeSH) of Immunomodulation, neural stem cell, and multiple sclerosis and all articles before January 2017 were included. The included studies had accurate data for immune mechanisms assessment and almost all reported neurologic clinical score assessment. Totally, 30 articles were eligible to be included in our systematic review out of 233 articles found at initial search. Studies showed exert immune modulation when neural stem cells (NSCs) are transplanted in the animal model of MS, experimental autoimmune encephalomyelitis (EAE). Regarding the potent immunomodulatory effects of neural stem cells (NSCs) and their beneficial effects in experimental autoimmune encephalomyelitis (EAE), including their capacity for neuroprotection and Immunomodulation it seems that NSCs may be a new therapeutic method in MS therapy.

Keywords: Immunomodulation, Neuroinflammation, Neural stem cell, Multiple sclerosis, Experimental
Full-Text [PDF 210 kb]   (20 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience



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Sheykhian S, Sahab Negah S. O 9: Immunomodulatory Effects of Neural Stem Cell on Multiple Sclerosis: A Systematic Review. Shefaye Khatam. 2017; 5 (S2) :9-9
URL: http://shefayekhatam.ir/article-1-1163-en.html
Back to browse issues page Volume 5 - The Supplement of Shefaye Khatam 2
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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