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Shefaye Khatam 2017, 5 - The Supplement of Shefaye Khatam 2: 23-23 Back to browse issues page
O 23: Anti-Inflammatory Treatment in Children with Refractory Seizure
M Beiraghi Toosi *, K Hassanpour, J Akhondian, F Ashrafzadeh, F Ebrahimzadeh
Mashhad University of Medical Sciences, Mashhad, Iran , beiraghitm1@gmail.com
Abstract:   (176 Views)

Epilepsy is a neurological disease of the central nervous system. It is estimated that about 50-70 million people worldwide suffer from this chronic disorder and 20 to 30% are resistant to conventional anti-epileptic drugs. In the epilepsy therapeutic arena, there is real need for developing novel antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the disease. Such treatments are still lacking. Numerous experimental and clinical findings demonstrate that brain inflammation plays a key role in the generation of seizures and the pathogenesis of epilepsy. Some conventional corticosteroid therapies are used for seizures in infantile spasm, lafora disease and Rasmussen syndrome. There are some herbal drugs that have anti-inflammatory effects but small side effects, like curcumin. Curcumin is the active component of turmeric which is used in every day cooking. Molecular investigations reveal that curcumin has anti-inflammatory, antimicrobial, anti-hepatotoxic and anti-hyperlipidemic affects. Curcumin has recently been reported to have anticonvulsant effects in several animal models of epilepsy and in our investigation, has effect on refractory myoclonic seizures in children with no significant side effect.

Keywords: Refractory seizure, Anti-inflammatory treatment, Curcumin
Full-Text [PDF 206 kb]   (71 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience



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Beiraghi Toosi M, Hassanpour K, Akhondian J, Ashrafzadeh F, Ebrahimzadeh F. O 23: Anti-Inflammatory Treatment in Children with Refractory Seizure. Shefaye Khatam. 2017; 5 (S2) :23-23
URL: http://shefayekhatam.ir/article-1-1176-en.html
Volume 5 - The Supplement of Shefaye Khatam 2 Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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