O 31: HTLV-1 and Inflammation
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Fariba Zemorshedi * |
Mashhad University of Medical Sciences, Mashhad, Iran , fz6482@yahoo.com |
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Abstract: (2935 Views) |
Human T-lymphotrophic virus type 1 (HTLV-1) is a retrovirus that is thought to infect approximately 10-20 million people worldwide. The majority of infected individuals remain asymptomatic carriers lifelong. HTLV-1 is thought to cause both local and systemic inflammatory diseases. The most common inflammatory condition associated with HTLV-1 is HTLV-1 associated myelopathy/Tropical spastic paraparesis (HAM/TSP), which occur in 0.25% to 5% of infected individuals. Migration of HTLV-1 infected lymphocytes from periphery into CNS induce a strong immune response and subsequent development of HAM/TSP, which characterized by progressive spastic paraparesis, bladder dysfunction and mild sensory disturbance. HTLV-1 is also associated with other inflammatory conditions such as myositis, uveitis, dermatitis, Alveolitis/bronchiectasis, arthritis and nephritis. |
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Keywords: Inflammation, HTLV, CNS |
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Full-Text [PDF 199 kb]
(757 Downloads)
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Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Basic research in Neuroscience
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