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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 41-41 Back to browse issues page
P 10: Safranal Attenuates Quinolinate-Induced Oxidative OLN-93 Cells Death
Sahar Fanoudi , Hamid R Sadeghnia *, Ameneh Veisifard , Mohammmad Soukhatanloo
a. Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , hsadeghnia@gmail.com
Abstract:   (273 Views)

Introduction: Quinolinic acid (QA) is a product of tryptophan degradation and its pathologic accumulation has been found to induce neuroinflammatory and demyelinating diseases such as multiple sclerosis via excessive free radicals generation. Recent studies showed Safranal which is the main component of essential oil of saffron, has several pharmacological effects such as antioxidant, anti-inflammatory and neuroprotective properties. The aim of this study was evaluation of the protective effect of Safranal on oxidative OLN-93 cells death induced by QA. Materials and Methods:  Cells were pretreated with Safranal (1-800 𝜇M) for 2 h and then were subjected to QA (8 mM) for 24 h in which the same treatments were applied. Cell viability and the parameters of redox status including the levels of intracellular reactive oxygen species (ROS), and lipid peroxidation were measured using 2-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT), 2,7-dicholorofluorecin diacetate (DCF-DA) and thiobarbituric acid assays, respectively. Results: safranal at concentration ranges of 1-800 μM had no toxic effect on cell viability (p>0.05). Treatment with Safranal significantly increased cell viability following QA insult at concentrations 1-800 𝜇M (p<0.001). Cytoprotective potential of Safranal also ameliorated ROS accumulation and lipid peroxidation induced by QA. Conclusion: These data suggest that Safranal exhibits oligoprotection potential by means of alleviating oxidative stress parameters.

Keywords: Quinolinic acid, Safranal, OLN-93 cells, Gliotoxicity
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience



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Fanoudi S, Sadeghnia H R, Veisifard A, Soukhatanloo M. P 10: Safranal Attenuates Quinolinate-Induced Oxidative OLN-93 Cells Death . Shefaye Khatam. 2017; 5 (S2) :41-41
URL: http://shefayekhatam.ir/article-1-1195-en.html
Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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