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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 43-43 Back to browse issues page
P 12: Study of the Association between Serum Level of Cystatin C and Behavioral Symptoms of 6-Hydroxydopamine – Induced Parkinsonism in Rat
Ali Sarbazi Golezari *, Nafiseh Rastgoo , Ayda Faraji , Tahereh Dargahi , Gilda Khandan , Arvin Babayan , Hashem Haghdoost Yazdi
a. Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran b. Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran , ali@doctor.com
Abstract:   (281 Views)

Introduction: Parkinson’s disease (PD) is the second most neurodegenerative disorder which is characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Clinical symptoms do not appear until approximately 70% of dopaminergic neurons and 80% of the striatal dopaminergic terminals have been lost. Thus, detecting nonclinical factors such as detecting biomarker for PD is necessary. In this study, we evaluate the serum level of Cystatin C as a possible biomarker of PD in 6-hydroxydopamine (6-OHDA)-induced Parkinsonism in rat. Materials and Methods:  Rats were divided into two groups: Parkinson and Control. 6-OHDA was administered by stereotaxic surgery into forebrain bundle. Severity of the Parkinsonism was evaluated by Apomorphine (APO)-induced rotational test at the third and sixth week’s post-surgery. Also, serum level of Cystatin C was measured before surgery and at the third and sixth weeks post-surgery. Results: Although rats of control group didn’t show a significant response to APO, rats of parkinson group showed significant rotations. The rotations at the sixth week’s post-surgery were significantly more than the rotations at the third week’s post-surgery. However, there was no significant difference between serum level of Cystatin C in rats of control and parkinson group. Also, there was no difference between serum level of Cystatin C in rats of parkinson group before and after the surgery. There was no difference between serum level of Cystatin C and severity of symptoms in rats of parkinson group. Conclusion: Our data show that in 6-OHDA animal model of PD, serum level of Cystatin C cannot predict onset or progress of PD and therefore this compound cannot consider as a biomarker for PD. 

Keywords: 6-hydroxydopamine, Animal model of parkinson, Apomorphine-induced rotational test, Cystatin C
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience



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Sarbazi Golezari A, Rastgoo N, Faraji A, Dargahi T, Khandan G, Babayan A et al . P 12: Study of the Association between Serum Level of Cystatin C and Behavioral Symptoms of 6-Hydroxydopamine – Induced Parkinsonism in Rat. Shefaye Khatam. 2017; 5 (S2) :43-43
URL: http://shefayekhatam.ir/article-1-1197-en.html
Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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