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Shefaye Khatam 2017, 5 - The Supplement of Shefaye Khatam 2: 47-47 Back to browse issues page
P 16: The Effect of Reducing CCL11 on Multiple Sclerosis Treatment by Using Heterochronic Parabiosis Techniques
Leila Kamali-Dolatabadi *, Masoomeh Mohamadpour
Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran , leili_kamali@yahoo.com
Abstract:   (187 Views)

Introduction: Multiple sclerosis is a chronic neuroinflammatory disease that leads to distribute neurodegeneration in the grey and white matter of the brain.  In MS, age-related iron accumulation, chronic oxidative injury and activation of microglia are key factors to create neurodegeneration. Also concentration of CCL11 is increased in   multiple sclerosis. CCL11 can amplify glutamate mediated neurotoxicity and inhibit neurogenesis. Materials and Methods: A model of Heterochronic Parabiosis is created with joining a sick animal to healthy young animal. Results: It is expected by reducing CCl11, healthy young blood could be effective in slowing and improving disease. Conclusion: Other studies suggest that multiple sclerosis treatment should be based on a combination of anti-inflammatory, regenerative, and neuroprotective strategies. By using heterochronic parabiosis has been shown that, young blood can rejuvenate and improve the regenerative capacity of peripheral tissues and central nervous system in aged animals. GDF11 is a systemic ‘pro-youthful' factor in young parabiont, that promote neurogenesis and rejuvenate regeneration capacity of CNS and promote tissue regeneration.  So it seems high concentration of GDF11 and low concentration of ccl11 in healthy young parabiont may be effective on regenerative capacity of central nervous system in MS animals.

Keywords: Multiple sclerosis, Neurodegeneration, Heterochronic parabiosis, CCL11, GDF11
Full-Text [PDF 217 kb]   (82 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Kamali-Dolatabadi L, Mohamadpour M. P 16: The Effect of Reducing CCL11 on Multiple Sclerosis Treatment by Using Heterochronic Parabiosis Techniques. Shefaye Khatam. 2017; 5 (S2) :47-47
URL: http://shefayekhatam.ir/article-1-1201-en.html
Volume 5 - The Supplement of Shefaye Khatam 2 Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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