P 19: The Effects of Aloe Vera Extract on Brain Edema and Blood-Brain Barrier Permeability after Traumatic Brain Injury
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Marzieh Shahriari , Mohammad Khaksari * , Bahram Bibak , Affat Ramshini , Abbas Shahabi |
Physiology Research Center, Institute of Neuropharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran , khaksar38@yahoo.co.uk |
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Abstract: (3460 Views) |
Introduction: Recent studies have reported that the Aloe vera (Aloe barbadensis miller) plant has anti-inflammatory and antioxidant effects. This study evaluated the neuroprotective effects of different doses of Aloe vera extract after traumatic brain injury (TBI) in male rats. Materials and Methods: In this study, 70 male rats were divided into 2 groups; each group consists of 5 of sub-groups as following: sham, TBI, TBI + vehicle, TBI + Aloe vera extract (low dose, 200mg/kg) and TBI + Aloe vera extract (high dose, 400mg/kg) groups. TBI was induced by the Marmarou method, and Aloe vera extract was administrated intra peritoneal (ip) 30 min after TBI. Brain edema was evaluated by measuring brain water content 24 h after the TBI and blood-brain barrier (BBB) permeability was determined by measuring Evans blue dye content 5 h after the TBI. Results: Our results showed that brain water contents was no significant difference in TBI group compared to TBI + vehicle group (P<0.687). But Aloe vera extract administration after TBI in different doses (200, 400 mg/kg) significantly reduced brain water content in TBI group compared to TBI + vehicle group (P<0.005). Also blood-brain barrier permeability significantly increased after TBI compared to vehicle group (P<0.001).In addition there was no significant difference in TBI group compared to TBI + vehicle group (P<0.742). But Aloe vera extract administration after TBI in different doses (200, 400 mg/kg) significantly reduced blood-brain barrier permeability in TBI group compared to TBI + vehicle group (P<0.001). Of course, high doses of aloe vera could more effectively reduced the brain blood barrier permeability compared to low dose of aloe vera. Conclusion: The current study, show that the Aloe vera extract may be had neuroprotetection effects after TBI. However, the mechanism(s) for this effect have not yet been elucidated. |
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Keywords: Tbi, Brain edema, Aloe vera |
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Full-Text [PDF 222 kb]
(1171 Downloads)
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Type of Study: Research --- Open Access, CC-BY-NC |
Subject:
Basic research in Neuroscience
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