[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
:: Volume 5 - The Supplement of Shefaye Khatam 2 ::
Back to browse issues page Shefaye Khatam 2017, 5 - The Supplement of Shefaye Khatam 2: 50-50
P 19: The Effects of Aloe Vera Extract on Brain Edema and Blood-Brain Barrier Permeability after Traumatic Brain Injury
Marzieh Shahriari, Mohammad Khaksari *, Bahram Bibak, Affat Ramshini, Abbas Shahabi
Physiology Research Center, Institute of Neuropharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran , khaksar38@yahoo.co.uk
Abstract:   (70 Views)

Introduction: Recent studies have reported that the Aloe vera (Aloe barbadensis miller) plant has anti-inflammatory and antioxidant effects. This study evaluated the neuroprotective effects of different doses of Aloe vera extract after traumatic brain injury (TBI) in male rats. Materials and Methods:  In this study, 70 male rats were divided into 2 groups; each group consists of 5 of sub-groups as following: sham, TBI, TBI + vehicle, TBI + Aloe vera extract (low dose, 200mg/kg) and TBI + Aloe vera extract (high dose, 400mg/kg) groups. TBI was induced by the Marmarou method, and Aloe vera extract was administrated intra peritoneal (ip) 30 min after TBI. Brain edema was evaluated by measuring brain water content 24 h after the TBI and blood-brain barrier (BBB) permeability was determined by measuring Evans blue dye content 5 h after the TBI. Results: Our results showed that brain water contents was no significant difference in TBI group compared to TBI + vehicle group (P<0.687). But Aloe vera extract administration after TBI in different doses (200, 400 mg/kg) significantly reduced brain water content in TBI group compared to TBI + vehicle group (P<0.005). Also blood-brain barrier permeability significantly increased after TBI compared to vehicle group (P<0.001).In addition there was no significant difference in TBI group compared to TBI + vehicle group (P<0.742). But Aloe vera extract administration after TBI in different doses (200, 400 mg/kg) significantly reduced blood-brain barrier permeability in TBI group compared to TBI + vehicle group (P<0.001).  Of course, high doses of aloe vera could more effectively reduced the brain blood barrier permeability compared to low dose of aloe vera. Conclusion: The current study, show that the Aloe vera extract may be had neuroprotetection effects after TBI. However, the mechanism(s) for this effect have not yet been elucidated.

Keywords: Tbi, Brain edema, Aloe vera
Full-Text [PDF 222 kb]   (34 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shahriari M, Khaksari M, Bibak B, Ramshini A, Shahabi A. P 19: The Effects of Aloe Vera Extract on Brain Edema and Blood-Brain Barrier Permeability after Traumatic Brain Injury. Shefaye Khatam. 2017; 5 (S2) :50-50
URL: http://shefayekhatam.ir/article-1-1204-en.html
Back to browse issues page Volume 5 - The Supplement of Shefaye Khatam 2
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.063 seconds with 794 queries by yektaweb 3392