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Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 120-120 Back to browse issues page
P 89: Reduction of Neuroinflammation in Epilepsy by Using Stem Cells Derived Astrocytes
Atena Adel Rastkhiz *
Neuroscience Department, Mashhad University of Medical Sciences, Mashhad, Iran , zahraadel646@yahoo.com
Abstract:   (1523 Views)

Epilepsy is neurological disorders that afflict many people around the world with a higher prevalence rate in children and in low income countries. Temporal lobe epilepsy (TLE) is result from hippocampal sclerosis is a neurological disorder with difficult treatment. Stem cells can transform into any type of cells such as glial cells, consequently stem cells can use for medical treatment. Stem cell therapy in epilepsy result in prophylaxis against epilepsy and improve cognitive function after seizures. Astrocytes   have many roles in the brain such as protection of neurons and endothelial cells, feeding, inhibiting over activation of microglia, modulate k changes, managing of extracellular ions, regulating density of y-amino butyric acid, glutamate and adenosine. Excessive activation of microglia cause brain inflammation that lead to epileptic seizures. Adult cell from patient have the capability to alter to embryonic cell and become stem cell by using transcription factors. Astrocytes by secretion of glial cell derived neurotrophic factor (GDNF), controlling the proliferation, adheration and movement of microglial cells .also astrocytes reduce generation of lipopolysaccharide (LPS), IL1B, TNF .astrocytes are as a source of protection mediators that decreased neuroinflammation. In this hypothesis I suggest using stem cell therapy in epilepsy to reduce neuroinflammation induced by microglia and reduce occurrence of seizures.

Keywords: Epilepsy, Stem cell therapy, Astrocytes, Treatment
Full-Text [PDF 202 kb]   (348 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Adel Rastkhiz A. P 89: Reduction of Neuroinflammation in Epilepsy by Using Stem Cells Derived Astrocytes. Shefaye Khatam. 2017; 5 (S2) :120-120
URL: http://shefayekhatam.ir/article-1-1275-en.html


Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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