:: Volume 5, Issue 4 (Autumn - 2017) ::
Shefaye Khatam 2017, 5(4): 37-46 Back to browse issues page
The Association of Functional Polymorphisms of IL-6 Gene Promoter with Stroke: Analysis in a Persian Population
Mohammad Reza Ghasemi, Peyman Zargari, Hamdam Hourfar, Maryam Pirhoushiaran, Payam Sasan Nezhad, Mahmoud Reza Azarpazhooh, Ariane Sadr-Nabavi *
a. Medical Genetic Research Center (MGRC), School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran c. Academic Center for Education, Culture, and Research (ACECR)-Khorasan Razavi, Mashhad, Iran , sadrnabavia2009@gmail.com
Abstract:   (2770 Views)

Introduction: Sequence variations in genes involved in inflammation system contribute to the risk of several cardiovascular diseases, such as stroke. Interleukin-6, a pleiotropic cytokine, is associated with cardiovascular disease, especially stroke. In other words, cerebral ischemia and inflammation are strongly linked. In the present study, we performed a genetic association study on two single nucleotide polymorphisms (IL6 -572 and -174 G>C) in an Iranian population in Khorasan province. Materials and Methods: Our hypothesis was tested in this case-control study on stroke patients as well as healthy controls that matched for age, sex, and some traditional risk factors. These polymorphisms were detected by Real time Taq man probe and PCR-RFLP. Results: After adjustment for the confounding risk factors, there was an association between the female patients who suffer from stroke and the IL-6 -572 G>C polymorphism and also Hemorrhagic subtype of stroke. Furthermore, there was no association between IL-6 -174 G>C and stroke, exceptone for one allele in male group. Conclusion: In conclusion, genotype of IL-6 -572 G>C May be a genetics risk factor that enhances the risk for stroke in studied population. However, it is highly controversial whether IL-6 -174 G>C is a susceptible gene for stroke in this population. This is needed to be confirmed in a larger population.

Keywords: Stroke, Inflammation, Polymerase Chain Reaction
Full-Text [PDF 1882 kb]   (722 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neurogenetics

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Volume 5, Issue 4 (Autumn - 2017) Back to browse issues page