[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
:: Volume 6 - The Spring Supplement of Shefaye Khatam 1 - ::
Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 8-8 Back to browse issues page
O8: Evaluating the Impact of Lactobacillus Acidophilus Probiotic Supplement on Sensory-Motor Recovery in a Model of Traumatic Brain Injury
Mohammad Moein Vakilzadeh , Ali Mehri , Amirhossein Heidari , Sara Pasban Bovanlo , Ali Gorji , Sajad Sahab Negah *
a. Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran , sahabnegahs@mums.ac.ir
Abstract:   (46 Views)

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide and many survivors experience a wide range of neurological impairments after TBI. Following the initial mechanical injury at the moment of a TBI event, various cellular and molecular processes are activated as the secondary injury. Neuroinflammation is an important mechanism involved in the secondary injury of TBI. Therefore, Neuroinflammation offers a promising opportunity for therapeutic intervention in order to prevent progressive tissue damage and improve the neurological recovery after TBI. The use of probiotics as a novel therapeutic option for modulating inflammatory response has received great attention, but there are still insufficient data on whether probiotics have the ability to regulate neuroinflammation, and further research needs to be done to elucidate the impact of probiotics on neuroinflammation and neurological recovery. If proven effective, probiotics can be used as a cheap, non-invasive, easy-to-use and safe treatment for modulating post-TBI neuroinflammation. Several studies have reported that probiotic compounds reduce serum inflammatory cytokines and increase the levels of anti-inflammatory cytokines. Hence, we hypothesize that using probiotics after TBI might have the potential to regulate neuroinflammatory response and thus, improve the neurological recovery.

Keywords: Neuroinflammation, Probiotics, Traumatic Brain Injury, TBI, Sensory-Motor Recovery
Full-Text [PDF 251 kb]   (15 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Vakilzadeh M M, Mehri A, Heidari A, Pasban Bovanlo S, Gorji A, Sahab Negah S. O8: Evaluating the Impact of Lactobacillus Acidophilus Probiotic Supplement on Sensory-Motor Recovery in a Model of Traumatic Brain Injury. Shefaye Khatam. 2018; 6 (S1) :8-8
URL: http://shefayekhatam.ir/article-1-1525-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 3647