[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
:: Volume 6 - The Spring Supplement of Shefaye Khatam 1 - ::
Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 14-14 Back to browse issues page
O14: Application of Neural Stem Cells Derived from Human Meningioma in Traumatic Brain Injury
Sajad Sahab Negah , Pardis Oliazadeh , Ali Jahanbazi Jahan Abad , Arezou Es'haghabadi , Sedigheh Ghasemi , Fatemeh Gholami , Ali Gorji *
a. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran c. Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany , gorjial@uni-muenster.de
Abstract:   (126 Views)

Traumatic brain injury is considered as one of the main causes of morbidity and mortality worldwide. Apart from primary mechanical injury, Secondary injuries due to inflammation and apoptosis result in great neuronal damage. Current treatments are not able to regenerate the damaged part and prevent future sequels. Using human stem cells with self-assembling scaffolds may be promising in treatment of traumatic brain injury. Human meningioma stem cells were isolated, cultured and expanded into in vitro condition. The rat models of TBI were divided into 5 groups: sham, PBS, stem cells, scaffold and stem cell+scaffold. mNSS and EEG were performed to evaluate movement and physical activity. IHC were done to assess cell differentiation. Inflammation and apoptosis markers like toll like receptors, caspase 3,8 and TNF-a were analyzed using western blotting and PCR methods. Results showed that inflammation was significantly reduced in cell group. Tissue engineering as a new therapeutic method can be promising in treating brain damage.

Keywords: Neural Tissue Enginnering, Trauamtic Brain Injury, Human Neural Stem Cells
Full-Text [PDF 251 kb]   (36 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sahab Negah S, Oliazadeh P, Jahanbazi Jahan Abad A, Es'haghabadi A, Ghasemi S, Gholami F et al . O14: Application of Neural Stem Cells Derived from Human Meningioma in Traumatic Brain Injury. Shefaye Khatam. 2018; 6 (S1) :14-14
URL: http://shefayekhatam.ir/article-1-1535-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3731