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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 18-18 Back to browse issues page
O18: Autoimmune Encephalitis (Pathophysiology, Clinical Signs and Diagnos Tic Tests)
Behnaz Sedighi *
Neuroogy Research Center, Kerman University of Medical Sciences, Kerman, Iran , behnaz.sedighi@gmail.com
Abstract:   (158 Views)
Autoimmune encephalitis is a difficult clinical diagnosis due to the similarities in the clini­cal, imaging and laboratory findings of many forms of autoimmune and infectious encephalitis.
Autoimmune encephalitis involves several types: The first group includes the classic paraneo­plastic disorders associated with antibodies to intracellular antigens. The second group involves autoantibodies to extracel­lular epitopes of ion channels, receptors and other associated proteins, such as the NMDA receptor. final group includes other forms of autoim­mune encephalitis in which precise antigens are less clearly established, such as lupus cerebritis or ADEM. The classical pre­sentation of encephalitis consists of subacute (days to a few weeks) progressive decrease in the level of consciousness, often with fluctuations, and altered cognition.
DIAGNOSTIC APPROACHES
  • Antibody testing Autoantibody testing is extremely important for the proper diagnosis of autoimmune encephalitis.
  • < >EEG
  • < >Cancer screening
Treatment Approaches: Treatment for suspected autoimmune encephalitis is often given empirically prior to specific antibody test results. This may include steroids and/or IVIG. If a cell-surface/synaptic antibody disorder is diagnosed, initial treatments may in­clude IVIG, plasmapheresis, and/or steroids. The proper diagnosis and management of autoimmune en­cephalitis requires an organized approach. Evaluation should begin with a detailed history and physical examination to detect clues to specific causes. A diverse range of infections should be considered, and appropriate testing should be done to exclude relevant pathogen.
 
Keywords: Autoimmune, Encephalitis, Paraneoplastic
Full-Text [PDF 242 kb]   (46 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Sedighi B. O18: Autoimmune Encephalitis (Pathophysiology, Clinical Signs and Diagnos Tic Tests). Shefaye Khatam. 2018; 6 (S1) :18-18
URL: http://shefayekhatam.ir/article-1-1541-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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