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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 46-46 Back to browse issues page
P15: Mephedrone Exposure in Pegnancy Iinduces Antiprolifrative and Proapoptotic Effects in Hippocampus of Mice Delivered Pups
Gholamreza Naseri * , Alireza Fazel , Mohammad Jafar Golalipour , Hossein Haghir , Hamid Sadeghian , Majid Mojarrad , Mahmoud Hosseini , Shokouh Shahrokhi Sabzevar , Farimah Beheshti , Ahmad Ghorbani
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , g_naseri@yahoo.com
Abstract:   (97 Views)

In recent years, abuse of synthetic cathinones, in particular, mephedrone, has increased among young adults worldwide. The study aim is to investigate the effects of mephedrone exposure during the gestational period on mice offspring outcomes, focusing on hippocampal neurotoxicity. The pregnant mice received mephedrone (50mg/kg, sc) on a regular schedule (once daily on all days, from day 5 to 18 of gestation) or repeated schedule (thrice daily on day 5, 6, 11, 12, 17, and 18 of gestation) to simulate regular or recreational use of mephedrone, respectively. Immunohistochemistry and TUNEL assay showed an inhibition of cell proliferation (p<0.05) and an increase of apoptosis (p<0.05) in the hippocampus of delivered pups of the repeated schedule mephedrone group. In conclusion, the present study has shown that repeated use of mephedrone impairs learning and memory processes through hippocampal damage.

Keywords: Hippocampus, Mice, Memory
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Naseri G, Fazel A, Golalipour M J, Haghir H, Sadeghian H, Mojarrad M, et al . P15: Mephedrone Exposure in Pegnancy Iinduces Antiprolifrative and Proapoptotic Effects in Hippocampus of Mice Delivered Pups. Shefaye Khatam. 2018; 6 (S1) :46-46
URL: http://shefayekhatam.ir/article-1-1593-en.html


Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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