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Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 187-187 Back to browse issues page
P156: Effect of Air Pollution on Alzheimer's Disease
Sara Abbasi *, Motahareh Mirdoosti Seyedeh, Hojjat Shadman Zahroodi, Mohammad Mirzaei
Mashhad University of Medical Sciences, Mashhad, Iran , maah.titi.1997297@gmail.com
Abstract:   (1051 Views)
Alzheimer, a chronic neurodegenerative disease, usually starts slowly and worsens gradually. It causes 60% to 70% of dementia cases. Difficulty in remembering recent events (short-term memory loss) is the most prominent early symptom. As the disease progresses, patients may have problems such as impaired language, disorientation (including easily getting lost), mood swings, loss of motivation, not managing self-care, and behavioral issues. The potential damaging effect of air pollution on the central nervous system is also investigated and therechr('39')s mounting evidence of a link between air pollution exposure and neurodegenerative pathologies, especially Alzheimerchr('39')s disease. Air pollution is thought to increase the risk of neurological diseases by developing neuro-inflammation, oxidative stress, glial activation and cerebrovascular damage. In animal models, contaminated particles can activate microglial cells and increase the secretion of IL-6, IL-1b, and TNF-a, leading to neuro-inflammation. Also, exposure to complex mixtures of air pollutants produces inflammation in the upper and lower respiratory tract and causes systemic inflammation; As a result, neuro-inflammation and neuropathology then lead to Alzheimer. In polluted regions, we expect a higher level of systemic inflammation, prefrontal white matter hyper-intensities, and hallmarks of Alzheimer.
Keywords: Air Pollution, Neuro Inflammation, Neuropathology, Alzheimer`S Disease
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Abbasi S, Mirdoosti M, Shadman Zahroodi H, Mirzaei M. P156: Effect of Air Pollution on Alzheimer's Disease. Shefaye Khatam. 2018; 6 (S1) :187-187
URL: http://shefayekhatam.ir/article-1-1662-en.html

Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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