:: Volume 6 - The Spring Supplement of Shefaye Khatam 1 - ::
Shefaye Khatam 2018, 6 - The Spring Supplement of Shefaye Khatam 1 -: 189-189 Back to browse issues page
P158: Targeting of Microglial M1/M2 Polarization Through Stem Cells Therapy as A Promising Candidate in Traumatic Brain Injury (TBI)
Fatemeh Barzegar-Dastgerdi *, Behrang Alani, Saeed Bagheri-Mohammadi, Mahdi Noureddini, Javad Verdi, Mohammad Shabani
a. Department of Applied Cell Sciences, Medicine Faculty, Kashan Medical University, Kashan, Iran b. Department of Medical Physics and Radiology, Paramedicine Faculty, Kashan Medical University, Kashan, Iran , Fbarzegar76@yahoo.com
Abstract:   (1460 Views)
Traumatic brain injury is a serious global health problem with irreversible high morbidity and disability and Because of its unknown pathophysiological mechanisms, efficient therapeutic approaches to improve the poor outcome and long-term impairment of behavioral function are still remains lacking. The microglial cells are the resident macrophage cells of the brain and have M1/M2 phenotype, for expression of pro-inflammatory and anti-inflammation cytokines, respectively. The results have been shown that pharmacological inhibiting of M1 phenotype and activating M2 phenotype of microglial cells could relieve cerebral injuries and increase neurological function recovery after Traumatic brain injury. Mesenchymal Stem Cells (MSCs), a type of multipotent stem cells, are regarded as promising therapies in several CNS diseases clinical trials. In animal models, transplantation of stimulated MSCs could promote the activation of microglia via transforming the classic M1phenotype into alternative M2 phenotype to inhibits the release of pro-inflammatory cytokines and raise tissue repair after traumatic brain injury (TBI). In this review, we summarized the beneficial effects of MSCs on TBI damaged tissues and their function in regulating the immune system to maintain the CNS. Although, lab trials studies have also confirmed that MSCs are able to promote positive outcomes in TBI models, however, there are still some unanswered questions regarding MSCs-based therapy due to complex ethical and safety concerns.
Keywords: Microglial Polarization, Mesenchymal Stem Cells Therapy, Traumatic Brain Injury
Full-Text [PDF 252 kb]   (220 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

XML   Persian Abstract   Print

Volume 6 - The Spring Supplement of Shefaye Khatam 1 - Back to browse issues page