:: دوره 6، شماره 3 - ( تابستان - 1397 ) ::
دوره 6 شماره 3 صفحات 69-78 برگشت به فهرست نسخه ها
گیرنده‌های فعال شونده با پروتئیناز در سیستم عصبی، جنبه‌های فیزیولوژی و پاتولوژی
عاطفه امینیان، فرشید نوربخش*
گروه ایمونولوژی، دانشگاه علوم پزشکی تهران، تهران، ایران ، f-noorbakhsh@sina.tums.ac.ir
چکیده:   (500 مشاهده)
مقدمه: گیرنده‌های فعال شونده با پروتئیناز، خانواده‌ای متشکل از 4 گیرنده متصل شونده به G پروتئین هستند که با مکانیسم فعالسازی خاص آن‌ها مشخص می‌شود و مستلزم آشکار شدن لیگاند فعال کننده پروتئولیتیک است. تا به امروز چهار گیرنده PAR در انسان و پستانداران کشف شده است. هر چهار عضو خانواده PAR در سیستم عصبی بیان شده‌اند، جایی که نشان داده شده است، بر ریخت‌شناسی، تکثیر و عملکرد سلول عصبی تأثیر دارند. به‌علاوه  PARها در بیماری‌های التهابی و تحلیل برنده عصبی مانند بیماری آلزایمر، مالتیپل اسکلروز، دمانس ناشی از HIV و سکته‌های مغزی نقش معنی‌داری دارند. توزیع گسترده  PAR‌ها در سیستم عصبی و نقش آن‌ها در اختلالات مختلف، آن‌ها را به اهداف درمانی مناسبی برای اختلالات عصبی تبدیل نموده است. نتیجه‌گیری: در این مقاله ما نقش  PAR‌ها در سیستم عصبی محیطی و مرکزی در شرایط فیزیولوژی و نیز شرایط پاتولوژیک را مرور می‌کنیم.
واژه‌های کلیدی: گیرنده‌های فعال شونده با پروتئیناز، ترومبین، سیستم عصبی مرکزی
متن کامل [PDF 913 kb]   (125 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: نوروبيولوژي مولكولي
فهرست منابع
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دوره 6، شماره 3 - ( تابستان - 1397 ) برگشت به فهرست نسخه ها