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:: Volume 6, Issue 3 (Summer - 2018) ::
Shefaye Khatam 2018, 6(3): 35-42 Back to browse issues page
Effect of Aerobic Training During Pregnancy on Seizure-Induced Depression- in Mouse
Ayoob Sabaghi , Ali Heyrani * , Amir Kiani , Namdar Yousofvand
Faculty of Physical Education and Sport Sciences, Razi University, Kermanshah, Iran , iliaheirani2004@gmail.com
Abstract:   (639 Views)

Introduction: Depression during pregnancy is not uncommon. In addition, depression is more common in patients suffering from epilepsy. Aerobic activity has been reported to alleviate depression. The purpose of this study was to investigate the effect of aerobic training during pregnancy on seizure-induced depression. Materials and Methods: Pregnant mice were randomly divided to control, sham, and experiment groups. The pentylenetetrazol (PTZ) kindling was induced on days 14 to19 after pregnancy in the experiment group. Experiment group was divided to mice with and without aerobic activities. Aerobic activity was performed every day during pregnancy. The rate of depression in pregnant mice was measured between the 14th and 19th days of pregnancy once in 48 hours and two hours after PTZ injection. Results: Treatment with aerobic training significantly decreased seizure-induced depression as well as seizure severity in pregnant mice. Conclusion: The present study showed that aerobic training during pregnancy is positively associated with decreasing depression and severity of seizure in PTZ-treated mice.

Keywords: Exercise, Pregnancy, Seizures, Depression
Full-Text [PDF 820 kb]   (442 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Psycology
References
1. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014; 55(4): 475-82. [DOI:10.1111/epi.12550]
2. Ablah E, Hesdorffer DC, Liu Y, Paschal AM, Hawley S, Thurman D, et al. Prevalence of epilepsy in rural Kansas. Epilepsy Res. 2014; 108(4): 792-801. [DOI:10.1016/j.eplepsyres.2014.01.001]
3. Novakova B, Harris PR, Reuber M. Diurnal patterns and relationships between physiological and self-reported stress in patients with epilepsy and psychogenic non-epileptic seizures. Epilepsy Behav. 2017; 70(Pt A): 204-11.
4. Borthen I, Gilhus NE. Pregnancy complications in patients with epilepsy. Curr Opin Obstet Gynecol2012; 24(2): 78–83. [DOI:10.1097/GCO.0b013e32834feb6a]
5. Bjørk MH , Veiby G, Reiter SC, Berle JØ, Daltveit AK, Spigset O, et al. Depression and anxiety in women with epilepsy during pregnancy and after delivery: a prospective population-based cohort study on frequency, risk factors, medication ,andprognosis .Epilepsia. 2015; 56(1): 28-39. [DOI:10.1111/epi.12884]
6. Reiter SF, Veiby G, Daltveit AK, Engelsen BA, Gilhus NE. Psychiatric comorbidity and social aspects in pregnant women with epilepsy–the Norwegian Mother and Child Cohort Study. EpilepsyBehav. 2013; 29(2): 379-85. [DOI:10.1016/j.yebeh.2013.08.016]
7. Herba CM, Glover V, Ramchandani PG, Rondon MB. Maternal depression and mental health in early childhood: an examination of underlying mechanisms in low-income and middleincome countries. Lancet Psychiatry 2016; 3(10): 983–92. [DOI:10.1016/S2215-0366(16)30148-1]
8. Jarde A, Morais M, Kingston D, et al. Neonatal outcomes in women with untreated antenatal depression compared with women without depression: a systematic review and metaanalysis. JAMA Psychiatry. 2016; 73(8): 826–37. [DOI:10.1001/jamapsychiatry.2016.0934]
9. El-Rafie MM, Khafagy GM, Gamal MG. Effect of aerobic exercise during pregnancy on antenatal depression. Int J Womens Health; 2016; 8: 53-7.
10. Kornum JB, Nielsen RB, Pedersen L, Mortensen PB, Nørgaard M. Use of selective serotonin-reuptake inhibitors during early pregnancy and risk of congenital malformations: updated analysis. Clin Epidemiol. 2010; 2: 29-36. [DOI:10.2147/CLEP.S9256]
11. Sharma RK, Singh T, Mishra A, Goel RK. Relative safety of different antidepressants for treatment of depression in chronic epileptic animals associated with depression. J Epilepsy Res. 2017; 7(1): 25–32. [DOI:10.14581/jer.17005]
12. Josefsson T, Lindwall M, Archer T. Physical exercise intervention in depressive disorders: Metaanalysis and systematic review." Scand J Med Sci Sports. 2014; 24(2): 259–72. [DOI:10.1111/sms.12050]
13. De Almeida AA, Gomes da Silva S, Lopim GM, Vannucci Campos D, Fernandes J, Cabral FR, et al. Resistance exercise reduces seizure occurrence, attenuates memory deficits and restores bdnf signaling in rats with chronic epilepsy. Neurochem Res. 2017; 42(4): 1230-9. [DOI:10.1007/s11064-016-2165-9]
14. Hrncic D, Rasic-Markovic A, Lekovic J, Krstic D, Colovic M, Macut D, et al. Exercise decreases susceptibility to homocysteine seizures: the role of oxidative stress. Int J Sports Med. 2014; 35: 544–50.
15. Zhang B, Zhang J-W, Wang W-P, Dong R-F, Tian S, Zhang C. Effect of lamotrigine on epilepsyinduced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole-kindled animal model. Synapse. 2017; 71(2): doi: 10.1002/syn.21945. [DOI:10.1002/syn.21945]
16. Li B, Wang L, Sun Z, Zhou Y, Shao D, Zhao J, et al. The anticonvulsant effects of SR 57227 on pentylenetetrazole-induced seizure in mice. PLoS One. 2014; 9(4): e93158. doi: 10.1371/journal.pone.
17. Pourmotabbed A, Nedaei SE, Cheraghi M, Moradian S, Touhidi A, Aeinfar M, et al. Effect of prenatal pentylenetetrazol-induced kindling on learning and memory of male offspring. Neuroscience. 2011; 172: 205-11. [DOI:10.1016/j.neuroscience.2010.11.001]
18. Zybura-Broda K, Amborska R, AmbrozekLatecka M, Wilemska J, Bogusz A, Bucko J, et al. Epigenetics of epileptogenesis-evoked upregulation of matrix metalloproteinase-9 in hippocampus. PLoS One. 2016; 11(8): e0159745. doi: 10.1371/journal.pone.
19. Rajabzadeh A, Bideskan AE, Fazel A, Sankian M, Rafatpanah H, Haghir H. The effect of PTZ-induced epileptic seizures on hippocampal expression of PSA-NCAM in offspring born to kindled rats. J Biomed Sci. 2012;19: 56. doi: 10.1186/1423-0127-19-56. [DOI:10.1186/1423-0127-19-56]
20. Gomes FG, Gomes Da Silva S, Cavalheiro EA, Arida RM. Beneficial influence of physical exercise following status epilepticus in the immature brain of rats. Neuroscience. 2014; 274: 69-81. [DOI:10.1016/j.neuroscience.2014.05.024]
21. Majidi-Zolbanin J, Doosti MH, Kosari-Nasab M, Salari AA. Prenatal maternal immune activation increases anxiety- and depressive-like behaviors in offspring with experimental autoimmune encephalomyelitis. Neuroscience2015; 294: 69-81. [DOI:10.1016/j.neuroscience.2015.03.016]
22. Gomes da Silva S, de Almeida AA, Fernandes J, Lopim GM, Cabral FR, Scerni DA, et al. Maternal exercise during pregnancy increases bdnf levels and cell numbers in the hippocampal formation but not in the cerebral cortex of adult rat offspring. PloS One. 2016; 11(1): e0147200. doi: 10.1371/journal.pone.
23. Patten SB. Medical models and metaphors for depression. Epidemiol Psychiatr Sci .2015; 24(4): 303-8. [DOI:10.1017/S2045796015000153]
24. Wichers MC, Koek GH, Robaeys G, Verkerk R, Scharpé S, Maes M. IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity. Mol Psychiatry. 2005; 10(6): 538-44. [DOI:10.1038/sj.mp.4001600]
25. Vezzani A. Epilepsy and inflammation in the brain: overview and pathophysiology. Epilepsy Curr. 2014; 14(2): 3-7. [DOI:10.5698/1535-7511-14.s2.3]
26. Furtado M, Katzman MA. Examining the role of neuroinflammation in major depression. Psychiatry Res. 2015; 229(1-2): 27-36. [DOI:10.1016/j.psychres.2015.06.009]
27. McKay MS, Zakzanis KK. The impact of treatment on HPA axis activity in unipolar major depression. J Psychiatr Res. 2010; 44(3): 183-92. [DOI:10.1016/j.jpsychires.2009.07.012]
28. Gianluca S. Neuroplasticity and major depression, the role of modern antidepressant drugs. World J Psychiatry. 2012; 2(3): 49-57. [DOI:10.5498/wjp.v2.i3.49]
29. Sousa N, Cerqueira JJ, Almeida OF. Corticosteroid receptors and neuroplasticity. Brain Res Rev. 2008; 57: 561–70. [DOI:10.1016/j.brainresrev.2007.06.007]
30. Chen H, Lombès M, Le Menuet D. Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells. Mol Brain. 2017; 10(1): 12. doi: 10.1186/s13041-017-0295-x. [DOI:10.1186/s13041-017-0295-x]
31. Kerling A, Kück M, Tegtbur U, Grams L, Weber-Spickschen S, Hanke A. Exercise increases serum brain-derived neurotrophic factor in patients with major depressive disorder. J Affect Disord. 2017; 215: 152-5. [DOI:10.1016/j.jad.2017.03.034]
32. Robledo-Colonia AF, Sandoval-Restrepo N, Mosquera-Valderrama YF, et al. Aerobic exercise training during pregnancy reduces depressive symptoms in nulliparous women: a randomized trial. J Physiother. 2012; 58(1): 9-15. [DOI:10.1016/S1836-9553(12)70067-X]
33. Ploughman M. Exercise is brain food: the effects of physical activity on cognitive function. Dev Neurorehabil. 2008; 11(3): 236-40. [DOI:10.1080/17518420801997007]
34. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron. 2002; 34(1): 13-25. [DOI:10.1016/S0896-6273(02)00653-0]
35. Nokia M, Lensu S, Ahtiainen J, Johansson PP, Koch LG, Britton SL, et al. Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained. J Physiol. 2016; 594 (7): 1855-73. [DOI:10.1113/JP271552]
36. Abella V, Scotece M, Conde J, Pino J, Gonzalez-Gay MA, Gómez-Reino JJ. Leptin in the interplay of inflammation, metabolism and immune system disorders. Nat Rev Rheumatol. 2017; 13(2): 100-9. [DOI:10.1038/nrrheum.2016.209]
37. Kim, H, Kim IK, Song W. Lee J, Park S. The synergic effect of regular exercise and resveratrol on kainate-induced oxidative stress and seizure activity in mice. Neurochem Res. 2013; 38(1): 117-22. [DOI:10.1007/s11064-012-0897-8]
38. Arida RM, de Almeida AC, Cavalheiro EA, Scorza FA. Experimental and clinical findings from physical exercise as complementary therapy for epilepsy. Epilepsy Behav. 2013; 26(3): 273-8. [DOI:10.1016/j.yebeh.2012.07.025]
39. Arida RM, Cavalheiro EA, Silva AC, Scorza FA. Physical activity and epilepsy: proven and predicted benefits. Sports Med. 2008; 38: 607–15. [DOI:10.2165/00007256-200838070-00006]
40. Vannucci Campos D, Lopim GM, da Silva DA, de Almeida AA, Amado D, Arida RM. Epilepsy and exercise: an experimental study in female rats. Physiol Behav. 2017; 15(171): 120-6. [DOI:10.1016/j.physbeh.2016.12.040]



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Sabaghi A, Heyrani A, Kiani A, Yousofvand N. Effect of Aerobic Training During Pregnancy on Seizure-Induced Depression- in Mouse. Shefaye Khatam. 2018; 6 (3) :35-42
URL: http://shefayekhatam.ir/article-1-1748-en.html


Volume 6, Issue 3 (Summer - 2018) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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