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:: Volume 7, Issue 1 (Winter - 2019) ::
Shefaye Khatam 2019, 7(1): 43-50 Back to browse issues page
Effect of Seizure During Pregnancy on Pentylenetetrazol-Induced Seizure-Like Behavior and Serum GDNF Levels in Adult Male Mice Offspring
Ayoob Sabaghi , Ali Heyrani * , Amir Kiani , Namdar Yousofvand
Faculty of Physical Education and Sport Sciences, Razi University, Kermanshah, Iran , iliaheirani2004@gmail.com
Abstract:   (5316 Views)
Introduction: Epilepsy is a neurodevelopmental disorder and prenatal factors exert a profound influence on the development of the nervous system in the offspring. Therefore, this study was designed to investigate the effect of seizure during pregnancy on pentylenetetrazol (PTZ)-induced seizure-like behavior in adult male mice offspring. Materials and Methods: After pregnancy, mice were classified as: i) naive group; ii) seizure group, induction of seizure between the fourteenth and nineteenth days of pregnancy by application of PTZ; iii) sham group, received normal saline intraperitoneally during the fourteenth and nineteenth days of pregnancy; and iv) control group, pregnant mice without injection during pregnancy. At postnatal day 95, serum glial cell-derived neurotrophic factor (GDNF) levels and seizure susceptibility to PTZ in male offspring of all groups were evaluated. Results: The results showed that serum GDNF levels and seizure severity of offspring of mice in the seizure group were significantly higher than male offspring in the other group. Conclusion: The present findings showed that seizure during pregnancy may enhance seizure susceptibility in male offspring, possibly via increasing serum GDNF.
Keywords: Seizures, Pregnancy, Mice, Glial Cell Line-Derived Neurotrophic Factor
Full-Text [PDF 524 kb]   (1424 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience
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Sabaghi A, Heyrani A, Kiani A, Yousofvand N. Effect of Seizure During Pregnancy on Pentylenetetrazol-Induced Seizure-Like Behavior and Serum GDNF Levels in Adult Male Mice Offspring. Shefaye Khatam 2019; 7 (1) :43-50
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Volume 7, Issue 1 (Winter - 2019) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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