:: Volume 7, Issue 4 (Autumn 2019) ::
Shefaye Khatam 2019, 7(4): 8-16 Back to browse issues page
Effect of Seizure During Pregnancy on Cognitive and Motor Coordination Performances in Adult Male Offspring of Female Mice: The Role of Serum Corticosterone Level
Ayoob Sabaghi, Ali Heyrani *, Amir Kiani, Hosna Khazaee, Sana Sabaghi, Saber Beygie
Department of Motor Behavior, Faculty of Physical Education and Sport Sciences, Razi University, Kermanshah, Iran , iliaheirani2004@gmail.com
Abstract:   (726 Views)
Introduction: Human and animal models have demonstrated that seizure during pregnancy can cause cognitive and motor impairments in the offspring. However, the mechanisms of this effect need to be elucidated. The purpose of this study was to investigate the effect of seizure during pregnancy on cognitive and motor performances of the adult male offspring with an emphasis on the hypothalamic–pituitary–adrenal (HPA) axis. Materials and Methods: Adult female ICR mice were randomly separated into two groups that received intraperitoneally either saline or pentylenetetrazol (PTZ) for 30 days. Then the fully kindled mice and control animals were allowed to mate. PTZ administration during pregnancy was continued until delivery, while the control group received saline at the same time. The cognitive performance and period motor coordination of adult male offspring were evaluated by novel object recognition task and raised-beam task, respectively. Results: We found that maternal seizure during pregnancy leads to a significant cognitive and motor coordination deficiency as well as an enhancement of corticosterone serum levels in adult male offspring. Conclusion: These findings suggest that seizure in pregnancy leads to cognitive deficiency and motor coordination impairment in adult male offspring, possibly through increased corticosterone serum levels.
Keywords: Seizures, Pregnancy, Cognition, Mice, Corticosterone
Full-Text [PDF 633 kb]   (290 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience
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