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Resistance exercise in rats and its physiological and neurological application indices
Zeinab Rezaee *
Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran , z.rezaee2009@yahoo.com
Abstract:   (15 Views)
Introduction: One of the most fascinating applications of sports models lies in clinical studies, where they play an effective role in discovering preventive and therapeutic strategies for various disorders. By increasing resistance to environmental stress, these models can influence outcomes at humoral and immunological levels, as well as influence behavioral responses. The effects of resistance training on pain, anxiety, memory, and cognitive performance, alongside disorders such as metabolic syndrome, cardiovascular diseases, and musculoskeletal disorders, are important topics that have been explored in recent years in both human and animal studies. Resistance training models differ in their application, benefits, and limitations based on different factors, such as the method of load application, the type and intensity of stimuli used, and the extent of aerobic system involvement during exercise. Conclusion: Although various types of resistance training induce diverse physiological and neurological effects in the body, they have received less attention compared to endurance training. A notable point in resistance training is the need to control aerobic interference, which can affect energy requirements, goals, and outcomes. This review study describes and evaluates different types of resistance training in experimental mouse models, presenting both new exercise protocols and modified models to reduce and control potential injuries. Additionally, it discusses the most common applications of these training models and their associated physiological and neurological evaluation indicators.
 
Keywords: Central Nervous System, Brain-Derived Neurotrophic Factor, Behavior, Models, Animal
     
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience
References
1. Charro MA, Aoki Ms Fau -Coutts AJ, Coutts Aj Fau -Araújo RC, Araújo Rc Fau -Bacurau RF, Bacurau RF. Hormonal, metabolic and perceptual responses to different resistance training systems. Journal of sports medicine and physical fitness. 2010; 50(2): 229-34.
2. Zhang P, Tian B. Metabolic syndrome: an important risk factor for Parkinson's disease. Oxidative medicine and cellular longevity. 2014; 2014: 729194. [DOI:10.1155/2014/729194]
3. Hastings MH, Herrera JJ, Guseh JS, Atlason B, Houstis NE, Abdul Kadir A, et al. Animal Models of Exercise From Rodents to Pythons. Circulation research. 2022; 130(12): 1994-2014. [DOI:10.1161/CIRCRESAHA.122.320247]
4. Poole D, Copp S, Colburn T, Craig J, Allen D, Sturek M, et al. Guidelines for Animal Exercise and Training Protocols for Cardiovascular Studies. American journal of physiology-heart and circulatory physiology. 2020; 318. [DOI:10.1152/ajpheart.00697.2019]
5. Constans A, Pin-Barre C, Molinari F, Temprado JJ, Brioche T, Pellegrino C, et al. High-intensity interval training is superior to moderate intensity training on aerobic capacity in rats: Impact on hippocampal plasticity markers. Behaviral brain research. 2021; 1. [DOI:10.1016/j.bbr.2020.112977]
6. Pinho RA, Aguiar AS, Jr., Radák Z. Effects of Resistance Exercise on Cerebral Redox Regulation and Cognition: An Interplay Between Muscle and Brain. Antioxidants (Basel, Switzerland). 2019; 8. [DOI:10.3390/antiox8110529]
7. Rezaee Z, Marandi SM, Ghaedi K, Esfarjani F. Molecular Mechanisms of Neurotrophins Actions on Diseases of Nervous System. Genetics in the third millennium. 2015; 12(4): 3778-93.
8. Psilander N. The effect of different exercise regimens on mitochondrial biogenesis and performance: Karolinska Institutet; 2024.
9. Rezaee Z. Guidelines for animal models of endurance and resistance exercise. Journal of neuroscience methods. 2025: 110362. [DOI:10.1016/j.jneumeth.2025.110362]
10. Buhr TJ, Reed CH, Wee OM, Lee JH, Yuan LL, Fleshner M, et al. The persistence of stress-induced physical inactivity in rats: an investigation of central monoamine neurotransmitters and skeletal muscle oxidative stress. Frontiers in behavioral neuroscience. 2023; 17: 1169151. [DOI:10.3389/fnbeh.2023.1169151]
11. Jones AB, Gupton R, Curtis KS. Estrogen and voluntary exercise interact to attenuate stress-induced corticosterone release but not anxiety-like behaviors in female rats. Behavioral brain research. 2016; 311: 279-86. [DOI:10.1016/j.bbr.2016.05.058]
12. Mirjalili R, Shokouh E, Dehkordi NS, Afsari R, Shafia S, Rashidy-Pour A. Prior short-term exercise prevents behavioral and biochemical abnormalities induced by single prolonged stress in a rat model of posttraumatic stress disorder. Behavioral brain research. 2022; 428: 113864. [DOI:10.1016/j.bbr.2022.113864]
13. Burnley M. Invited review: The speed-duration relationship across the animal kingdom. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology. 2023; 279: 111387. [DOI:10.1016/j.cbpa.2023.111387]
14. Rezaee Z, Marandi S, Alaei H. Molecular Mechanisms of Exercise in Brain Disorders: a Focus on the Function of Brain-Derived Neurotrophic Factor-a Narrative Review. Neurotoxicity research. 2022; 40. [DOI:10.1007/s12640-022-00527-1]
15. Gomes MJ, Pagan LU, Lima ARR, Reyes DRA, Martinez PF, Damatto FC, et al. Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats. Journal of cellular and molecular medicine. 2020; 24(9): 5352-62. [DOI:10.1111/jcmm.15191]
16. Strickland JC, Abel JM, Lacy RT, Beckmann JS, Witte MA, Lynch WJ, et al. The effects of resistance exercise on cocaine self-administration, muscle hypertrophy, and BDNF expression in the nucleus accumbens. Drug and alcohol depend. 2016; 163: 186-94. [DOI:10.1016/j.drugalcdep.2016.04.019]
17. Al-Sarraf H, Mouihate A. Muscle Hypertrophy in a Newly Developed Resistance Exercise Model for Rats. Frontiers in physiology. 2022; 13. [DOI:10.3389/fphys.2022.851789]
18. Konhilas JP, Widegren U, Allen DL, Paul AC, Cleary A, Leinwand LA. Loaded wheel running and muscle adaptation in the mouse. American Journal of Physiology-Heart and Circulatory Physiology. 2005; 289(1): H455-65. [DOI:10.1152/ajpheart.00085.2005]
19. Poole DC, Burnley M Fau - Vanhatalo A, Vanhatalo A Fau - Rossiter HB, Rossiter Hb Fau - Jones AM, Jones AM. Critical Power: An Important Fatigue Threshold in Exercise Physiology. Medicine and science in sports and exercise. 2016; 48(11): 2320-34. [DOI:10.1249/MSS.0000000000000939]
20. Lourenço Í, Krause Neto W, Dos Santos Portella Amorim L, Moraes Munhoz Ortiz V, Lopes Geraldo V, Henrique da Silva Ferreira G, et al. Muscle hypertrophy and ladder-based resistance training for rodents: A systematic review and meta-analysis. Physiological reports. 2020; 8(17): e14502. [DOI:10.14814/phy2.14502]
21. Ishihara A, Roy Rr Fau - Ohira Y, Ohira Y Fau - Ibata Y, Ibata Y Fau - Edgerton VR, Edgerton VR. Hypertrophy of rat plantaris muscle fibers after voluntary running with increasing loads. Journal of applied physiolgy. 1988; 84(6): 2183-9. [DOI:10.1152/jappl.1998.84.6.2183]
22. Legerlotz K, Elliott B Fau -Guillemin B, Guillemin B Fau - Smith HK, Smith HK. Voluntary resistance running wheel activity pattern and skeletal muscle growth in rats. Experimental physiology. 2008; 93(6): 75. [DOI:10.1113/expphysiol.2007.041244]
23. Speakman JR. Measuring energy metabolism in the mouse - theoretical, practical, and analytical considerations. Frontiers in physiology. 2013; 4(24). [DOI:10.3389/fphys.2013.00034]
24. Nilsson MI, Greene Np Fau -Dobson JP, Dobson Jp Fau -Wiggs MP, Wiggs Mp Fau -Gasier HG, Gasier Hg Fau -Macias BR, Macias Br Fau -Shimkus KL, et al. Insulin resistance syndrome blunts the mitochondrial anabolic response following resistance exercise. American journal of physiology - Endocrinology and Metabolism. 2010; 999(3): E466-74. [DOI:10.1152/ajpendo.00118.2010]
25. Notomi T, Okazaki Y Fau -Okimoto N, Okimoto N Fau -Saitoh S, Saitoh S Fau -Nakamura T, Nakamura T Fau -Suzuki M, Suzuki M. A comparison of resistance and aerobic training for mass, strength and turnover of bone in growing rats. European Journal of Applied physiology. 2000; 83(6): 469-74. [DOI:10.1007/s004210000316]
26. Wirth O, Gregory Ew Fau -Cutlip RG, Cutlip Rg Fau -Miller GR, Miller GR. Control and quantitation of voluntary weight-lifting performance of rats. Journal of applied Physiolgy. 2003; 95(1): 402-12. [DOI:10.1152/japplphysiol.00919.2002]
27. Cassilhas RC, Lee Ks Fau -Fernandes J, Fernandes J Fau -Oliveira MGM, Oliveira Mg Fau -Tufik S, Tufik S Fau - Meeusen R, Meeusen R Fau -de Mello MT, et al. Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms. Neuroscience. 2012; 202: 309-17. [DOI:10.1016/j.neuroscience.2011.11.029]
28. Holloszy Jo Fau -Smith EK, Smith Ek Fau -Vining M, Vining M Fau -Adams S, Adams S. Effect of voluntary exercise on longevity of rats. Journal of applied Physiology. 1985; 59(3): 826-31. [DOI:10.1152/jappl.1985.59.3.826]
29. Strickland JC, Smith MA. Animal models of resistance exercise and their application to neuroscience research. Journal of neuroscience methods. 2016; (273). [DOI:10.1016/j.jneumeth.2016.08.003]
30. Cardozo D, Destro D. Exercise order in resistance training -a brief review of the acute effects on cardiovascular response in the post-exercise period. Research, society and development. 2022; 11: e272111335489. [DOI:10.33448/rsd-v11i13.35489]
31. Hornberger TA, Jr., Farrar RP. Physiological hypertrophy of the FHL muscle following 8 weeks of progressive resistance exercise in the rat. Canadian journal of applied physiology = Revue canadienne de physiologie appliquee. 2004; 29(1): 16-31. [DOI:10.1139/h04-002]
32. Carbone PO, Krause W, Gama EF, Silva WdA, Nobre TL, Caperuto EC, et al. Morphological adjustments of the radial nerve are intensity-dependent. Revista brasileira de medicina do esporte. 2017; 23: 55-9. [DOI:10.1590/1517-869220172301157903]
33. Padilha CS, Cella PS, Ribeiro AS, Voltarelli FA, Testa MTJ, Marinello PC, et al. Moderate vs high-load resistance training on muscular adaptations in rats. Life sciences. 2019; 238: 116964. [DOI:10.1016/j.lfs.2019.116964]
34. Chi CP, Hou CW, Wu YY, Wang TH, Yu SH. Night time resistance exercise alters muscular IL-6-related protein signaling, but not muscle growth after 10 weeks of resistance training in male rats. General physiology and biophysics. 2020; 39(1): 89-98. [DOI:10.4149/gpb_2019047]
35. Wang R, Tian H, Guo D, Tian Q, Yao T, Kong X. Impacts of exercise intervention on various diseases in rats. Journal of sport and health science. 2020; 9(3). [DOI:10.1016/j.jshs.2019.09.008]
36. Powers SK, Smuder AJ, Kavazis AN, Quindry JC. Mechanisms of exercise-induced cardioprotection. Physiology (Bethesda, Md). 2014; 29(1): 27-38. [DOI:10.1152/physiol.00030.2013]
37. Rodrigues EA, Lima ARR, Gomes MJ, Souza LM, Pontes THD, Pagan LU, et al. Influence of Isolated Resistance Exercise on Cardiac Remodeling, Myocardial Oxidative Stress, and Metabolism in Infarcted Rats. Antioxidants (Basel, Switzerland). 2023; 12. [DOI:10.3390/antiox12040896]
38. Wrann Christiane D, White James P, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, et al. Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway. Cell metabolism. 2013. [DOI:10.1016/j.cmet.2013.09.008]
39. Rafiei S, Bazyar Y, Edalatmanesh MA. Effect of Gallic Acid and Endurance Exercise Training on BDNF in a Model of Hippocampal Degeneration. The neuroscience journal of shefaye khatam. 2016; 4(1): 1-6. [DOI:10.18869/acadpub.shefa.4.1.1]
40. Aberg ND, Brywe KG, Isgaard J. Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain. The scientific world journal. 2006; 6: 53. [DOI:10.1100/tsw.2006.22]
41. Vilela TC, Muller AP, Damiani AP, Macan TP, da Silva S, Canteiro PB, et al. Strength and Aerobic Exercises Improve Spatial Memory in Aging Rats Through Stimulating Distinct Neuroplasticity Mechanisms. Molecular neurobiology. 2017; 54(10): 7928-37. [DOI:10.1007/s12035-016-0272-x]
42. Taguchi S, Choudhury ME, Mikami K, Utsunomiya R, Yano H, Tanaka J. Treadmill Exercise as a Preventive Measure Against Age-Related Anxiety and Social Behavioral Disorders in Rats: When Is It Worth Starting? Annals of rehabilitation medicine. 2022; 46. [DOI:10.5535/arm.22105]
43. Valilu mr, Mehran S, Mosarrezaii A, Mahmodi S, Gholinejad Z. Biomarkers of Neurological Diseases: A Comprehensive Review of Literature. The neuroscience journal of shefaye khatam. 2024; 12(2): 102-13. [DOI:10.61186/shefa.12.2.102]
44. Rezaee Z, marandi m, alaei h, esfarjani f. The Effect of Exercise on Parkinson's Disease. The neuroscience journal of shefaye khatam. 2020; 9(1): 189-99. [DOI:10.52547/shefa.9.1.189]
45. Naderi A, Saremi A, Afarinesh khaki Mr. Comparison of twelve weeks of endurance and resistance exercise on the levels of acetylcholine and interleukin-1 beta in Alzheimer's male rats. The neuroscience journal of shefaye khatam. 2024; 12(3): 55-63. [DOI:10.61186/shefa.12.3.55]
46. Høydal MA, Wisløff U Fau - Kemi OJ, Kemi Oj Fau - Ellingsen O, Ellingsen O. Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training. European journal of cardiovascular prevention and rehabilitation. 2007; 14(6): 753-60. [DOI:10.1097/HJR.0b013e3281eacef1]
47. Sadeghi m, nazem f, komaki a. The Effect of Aerobic Exercise-induced Chronic Fatigue on Brain-Derived Neurotrophic Factor as well as Memory and Learning in Male Wistar Rats. The neuroscience journal of shefaye khatam. 2024; 13(1): 51-62. [DOI:10.61186/shefa.13.1.51]
48. De Souza MR, Pimenta L, Pithon-Curi TC, Bucci M, Fontinele RG, De Souza RR. Effects of aerobic training, resistance training, or combined resistance-aerobic training on the left ventricular myocardium in a rat model. Microscopy research and technique. 2014; 77(9): 727-34. [DOI:10.1002/jemt.22394]

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