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:: Volume 1, Issue 1 (Winter - 2013) ::
Shefaye Khatam 2013, 1(1): 31-36 Back to browse issues page
The Effect of Spreading Depression on Glycoconjugates of Dentate Gyrus in Rats
Maryam Jafarian * , Fariba Karimzadeh , Sadegh Rahimi , Seyed Mahmoud Hosseini , Elham Mohammadzadeh , Alireza Fazel
Deptartment of Anatomy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , jafaryanm@yahoo.com
Abstract:   (7931 Views)
Introduction: Spreading depression (SD) is a pathophysiological phenomenon caused by repetitive depolarization of neurons and glial cells. There is a relationship between SD and some disorders, such as migraine with aura. Glycoconjugates play an important role in cell proliferation and differentiation. It has been shown that SD can stimulate the neurogenesis. In the present study, the effect of SD on expressing and distribution of glycoconjugates was evaluated. Materials & Methods: Forty rats (30-45 days) were divided into two groups: 1 week and 1 month each group was contained three subgroups: control, sham and SD. Two and four SD was induced by KCL injection in 1 week and 1 month groups, respectively. Histochemical studies were performed by using five different horse radish peroxidase labeled lectins, including PNA, VVA, MPA and LTA in polymorph layer of hippocampal dentate gyrus. Results: There were no differences in the expression of three lectins (PNA, VVA, and MPA) in all different groups. However, induction of SD significantly enhanced the expression of LTA compared with sham and control groups. Conclusion: Higher intensity reaction of LTA indicates a possible role of L-focuses monosaccharide in changes of synaptic plasticity induced by SD.
Keywords: Cortical Spreading Depression, Dentate Gyrus, Lectins
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neurophysiopathology



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Jafarian M, Karimzadeh F, Rahimi S, Hosseini S M, Mohammadzadeh E, Fazel A. The Effect of Spreading Depression on Glycoconjugates of Dentate Gyrus in Rats. Shefaye Khatam. 2013; 1 (1) :31-36
URL: http://shefayekhatam.ir/article-1-26-en.html


Volume 1, Issue 1 (Winter - 2013) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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