[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Home::
Journal Information::
Articles Archive::
Guide for Authors::
For Reviewers::
Ethical Statements::
Registration::
Site Facilities::
Contact us::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Copyright Policies

 

AWT IMAGE

 

..
Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

..
:: Volume 2 - The Summer Supplement of Shefaye Khatam 1 - ::
Shefaye Khatam 2014, 2 - The Summer Supplement of Shefaye Khatam 1 -: 160-160 Back to browse issues page
P136: Role of Muscarinic Receptors in Schizophrenia
Milad Ahmadi * , Hassan Hosseini Ravandi , Afsaneh Aghabarari
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. , pmiladz@gmail.com
Abstract:   (4885 Views)
Schizophrenia is a severe psychiatric illness with a lifetime prevalence of ˜1% that imposes a huge toll on patients, their families and public health services worldwide. Delusions, hallucinations, disorganized speech, grossly disorganized or catatonic behavior and negative symptoms constitute the core symptoms of schizophrenia. Although the neurotransmitter dopamine plays a prominent role in the pathogenesis and treatment of schizophrenia, the dopamine hypothesis of schizophrenia fails to explain all aspects of this disorder. Neuropsychopharmacological studies have focused on the role of different neurotransmitter systems in schizophrenia and led to hypotheses as to the causes of this disorder. Since the beginning of the last century, acetylcholine has been recognized as a neurotransmitter both in the CNS as well as the peripheral nervous system. Acetylcholine is synthesized in neurons from acetyl-CoA and choline in a reaction catalyzed by the enzyme choline acetyl transferase, an enzyme that is almost exclusively located in high concentrations in cholinergic neurons. Evidence for an involvement of the muscarinic cholinergic receptors in schizophrenia has been gained from the study of CNS tissue obtained postmortem. Few studies have so far assessed the distribution of cholinergic neurons in schizophrenia. This review will focus on evidence that supports the hypothesis that the muscarinic system is involved in the pathogenesis of schizophrenia and that muscarinic receptors may represent promising novel targets for the treatment of this disorder.
Keywords: Schizophrenia, Muscarinic, Muscarinic Agonists, Muscarinic Antagonists, Etiology
Full-Text [PDF 140 kb]   (1154 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Psycology


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ahmadi M, Hosseini Ravandi H, Aghabarari A. P136: Role of Muscarinic Receptors in Schizophrenia. Shefaye Khatam 2014; 2 (S1) :160-160
URL: http://shefayekhatam.ir/article-1-263-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 2 - The Summer Supplement of Shefaye Khatam 1 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.06 seconds with 45 queries by YEKTAWEB 4645