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:: Volume 1, Issue 2 (Spring - 2013) ::
Shefaye Khatam 2013, 1(2): 45-49 Back to browse issues page
Hippocampal NMDA receptor in an animal model of absence seizure
Fariba Karimzadeh *, Milad Ahmadi, Mostafa Modarres Mousavi, Fatemeh Alipour
Shefa Neuroscience Research Center, Tehran, Iran. , Fariba_karimzade@yahoo.com
Abstract:   (5557 Views)

Introduction: The glutamergic receptors affect the synchronization of spike and wave discharges in different animal models of absence seizure. We studied the distribution of a NMDA subtype receptor in CA1 area of the hippocampus. Materials and Methods: Expression of NMDA subreceptor R2, the predominant excitatory neurotransmitter receptor in the brain, was investigated in rats suffering from absence-like seizures. Results: Rats with absence-like seizures exhibited decreased number of these NMDA subreceptors in the hippocampal formation. Conclusion: Changes of expression of these receptors in the hippocampus may be involved in cognition deficits in absence epilepsy.

Keywords: Hippocampus, Epilepsy, Brain, Glutamates
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neurophysiopathology

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Karimzadeh F, Ahmadi M, Modarres Mousavi M, Alipour F. Hippocampal NMDA receptor in an animal model of absence seizure . Shefaye Khatam. 2013; 1 (2) :45-49
URL: http://shefayekhatam.ir/article-1-37-en.html

Volume 1, Issue 2 (Spring - 2013) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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