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:: Volume 1, Issue 3 (Summer - 2013) ::
Shefaye Khatam 2013, 1(3): 17-22 Back to browse issues page
Role of microRNAs in Central Nervous System Development
Farideh Talebi * , Samira Ghorbani Gazar
a. Tehran University of Medical Sciences, Tehran, Iran. b. Shefa Neuroscience Research Center, Tehran, Iran. , Talebi_f @hotmail.com
Abstract:   (4649 Views)

Introduction: Gene expression regulation is essential for correct functioning of the cell. Complex processes such as development, apoptosis, cell differentiation, and cell cycling require a fine tuning of gene expression. microRNAs (miRNAs) are small RNAs that have been recognized as key components of the gene expression regulatory machinery. microRNAs are a class of small RNA regulators that are involved in numerous cellular processes, including development, proliferation, differentiation, neurogenesis, and plasticity. miRNAs are critical contributors to the regulation of gene expression in the nervous system. Conclusion: Emerging evidence indicates that microRNAs regulate both the development and function of the nervous system. Deficiency in microRNA function has also been implicated in a number of neurological disorders. Understanding the roles of microRNAs will provide new insights into the complexity and operation of the nervous system.

Keywords: microRNAs, Nervous System, Neurogenesis, Nervous System Diseases
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience



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Talebi F, Ghorbani Gazar S. Role of microRNAs in Central Nervous System Development. Shefaye Khatam. 2013; 1 (3) :17-22
URL: http://shefayekhatam.ir/article-1-41-en.html


Volume 1, Issue 3 (Summer - 2013) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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