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:: Volume 1, Issue 3 (Summer - 2013) ::
Shefaye Khatam 2013, 1(3): 33-37 Back to browse issues page
Long-Term Potentiation Enhanced in Juvenile Rat by Repetitive Cortical Spreading Depression
Milad Ahmadi, Mehrnaz Banazadeh Dardashti, Mostafa Modarres Mousavi, Fariba Karimzadeh *
a. Shefa Neuroscience Research Center, Khatam-al-Anbia Hospital, Tehran, Iran.b. School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. , Fariba_karimzade@yahoo.com
Abstract:   (8167 Views)

Introduction: Spreading depression (SD) is a bioelectrical event in the central nervous system and involves in the pathophysiology of some neurological disorders. In this present study, we indicate enhancement of long-term potentiation of hippocampus tissue in juvenile rats faced to cortical spreading depression repetitively. Materials and Methods: Silver recording electrodes as well as a cannula were implanted over the brain of juvenile rats. Repetitive cortical SD events were induced by KCl 3 M weekly injection through the cannula. The brains were removed after 4 weeks. Transverse sections were prepared and incubated in artificial cerebrospinal fluid. Single electrical stimulations were applied through a bipolar electrode placed on to the hippocampal Schaffer collaterals. The field excitatory postsynaptic potentials (fEPSP) were elicited by adjusting the intensity of stimulation to 50% of that at which population spikes began to appear. Results: Repetitive SD enhanced the long-term potentiation in CA1 hippocampal area. The data indicate that repetitive cortical SD in juvenile rats significantly increases the amplitude of the fEPSP form the baseline. Conclusion: This may clarify the pathophysiology of memory deficit were seen in some neurological disorders in children.

Keywords: Long-Term Potentiation, Learning, Memory, Neuronal Plasticity, Hippocampus
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neurophysiopathology

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Ahmadi M, Banazadeh Dardashti M, Modarres Mousavi M, Karimzadeh F. Long-Term Potentiation Enhanced in Juvenile Rat by Repetitive Cortical Spreading Depression. Shefaye Khatam. 2013; 1 (3) :33-37
URL: http://shefayekhatam.ir/article-1-44-en.html

Volume 1, Issue 3 (Summer - 2013) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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