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:: Volume 1, Issue 4 (Autumn - 2013) ::
Shefaye Khatam 2013, 1(4): 22-28 Back to browse issues page
The Effect of MK-801 on Memory after Induction of Repetitive Spreading Depression in the Juvenile Rat
Babak Khodaie , Ahmad Ali Lotfinia , Mahmoud Lotfinia , Milad Ahmadi , Maryam Jafarian *
a. Shefa Neuroscience Research Center, Tehran, Iran. b. School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. , jafarian.m34@gmail.com
Abstract:   (6244 Views)
Introduction: The term cortical spreading depolarization (CSD) describes a wave of mass neuronal depolarization linked with ionic distribution and cellular swelling. Glutamate release following cell depolarization in extracellular space is a major event in this phenomenon. The hippocampus is widely accepted to play a pivotal role in memory. The aim of the present study was to evaluate the role of glutamate N-methyl-D-aspartate (NMDA) sub receptor on SD-induced memory deficits in rats. Materials and Methods: 36 juvenile Wistar rat were used to investigate the role of repetitive SD induction on memory performance by T-Maze test. We have investigated the role of MK-801, a NMDA receptor blocker, on the memory retrieval by the same test. Results: Behavioral assessments showed that memory retrieval significantly impaired following by the repetitive SD induction. However, application of MK-801 improved the memory deficits induced by the repetitive SD. Conclusion: Our data suggested that NMDA receptors may play a critical role on protection of memory in SD related disorders.
Keywords: Cortical Spreading Depression, Hippocampus, Memory, Brain
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neurophysiopathology



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Khodaie B, Lotfinia A A, Lotfinia M, Ahmadi M, Jafarian M. The Effect of MK-801 on Memory after Induction of Repetitive Spreading Depression in the Juvenile Rat. Shefaye Khatam. 2013; 1 (4) :22-28
URL: http://shefayekhatam.ir/article-1-50-en.html


Volume 1, Issue 4 (Autumn - 2013) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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