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Optogenetics: Controlling the Function of Neural Cells with Light and its Applications
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Mohammad Javad Eslamizade *   |
| a. Shefa Neuroscience Research Center, Tehran, Iran. b. Laboratory of Intracellular Recording and Patch Clamping in Neurodegenerative Diseases, Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , eslamizademj@gmail.com |
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Abstract: (10595 Views) |
| Introduction: Manipulating the function of neural cells via electrophysiology and pharmacological agents in neuroscience research have long been interesting in unraveling the function of neural circuits, behavior, and attributed disorders. The power of electrophysiology and pharmacologic methods in the manipulation of neural cells varies and therefore researchers have been attempting to enhance their knowledge in this field in recent two decades. Optogenetics has the advantage to take under control both the temporal and spatial resolution in manipulating desired neural cells. In optogenetics, control over the function of neural cells is possible through shining the light onto the cells that bear light sensitive molecules. Conclusion: Optogenetics come to help the researchers to know how the neural cells, circuits, and systems work and there is an attempt to move toward the treatment of nervous system disorders by this technology. In this article, I reviewed optogenetics and its potential clinical applications. |
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| Keywords: Electrophysiology, Optogenetics, Opsins |
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Full-Text [PDF 2727 kb]
(2658 Downloads)
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Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Neurophysiopathology
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