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The Role of TRPV1 Receptors in the Brain Function
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Fatemeh Saffarzadeh   , Mahmoud Reza Hadjighassem * |
| Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. , mahmoudreza@hotmail.com |
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Abstract: (11748 Views) |
| Introduction: Transient receptor potential vanilloid 1 (TRPV1) belongs to a family of ligand gated ion channels. This non-selective cation channel is permeable to Na+, K+ and highly to Ca2+ ions. It acts as a trigger for Ca2+ mediated cell signaling. Although this channel has been previously found highly expressed in dorsal root ganglion, there is a line of evidence indicating the remarkable expression of TRPV1 channels in other parts of the central nervous system. Conclusion: There is evidence to suggest that TRPV1 channels in the brain contribute in many basic neuronal functions, including neurotransmitter release and synaptic plasticity. |
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| Keywords: TRPV1 receptor, Synaptic Transmission, Neuronal Plasticity |
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Full-Text [PDF 2219 kb]
(2766 Downloads)
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Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Neurophysiopathology
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