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Shefaye Khatam 2014, 2 - The Autumn Supplement of Shefaye Khatam 3 -: 108-108 Back to browse issues page
P58: Neurological Outcomes after Traumatic Brain Injury Affected by Concomitant Administration of Progesterone and Erythropoietin
Zahra Nourzad , Tahere Ghadiri , Arezou Eshaghabadi , Mostafa Modarres Mousavi Sayed *
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. , modarres.mousavi@gmail.com
Abstract:   (1914 Views)
Traumatic brain injury (TBI) is one of the most common neurological diseases with no definite treatment. Erythropoietin (Epo) and progesterone (Prog) have been shown to have neuroprotective effects in different types of experimental brain injury models. This study was designed to determine the effect of Epo, Prog and combination of Epo/Prog on neurological outcome after traumatic brain injury. Fifty-four male Wistar rats were divided into 5 groups including intact (n=6), TBI (n=12), TBI + 16 mg/kg Prog (n=12), TBI + 5000 U/kg Epo (n=12), TBI + 16 mg/kg Pro + 5000 U/kg Epo (n=12). Neurological evaluation was performed using modified Neurological Severity Score on days 1, 2, 7 and 14 post TBI. The results revealed that Prog and Epo individually ameliorated neurological deficit following TBI while the combination of Prog and Epo exacerbated the neurological dysfunction. In conclusion, our study indicates that the combination of Prog and Epo does not improve neurologic outcome after TBI.
Keywords: Traumatic Brain Injury, Progesterone, Neuroprotective
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neuropharmacology


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Nourzad Z, Ghadiri T, Eshaghabadi A, Modarres Mousavi M. P58: Neurological Outcomes after Traumatic Brain Injury Affected by Concomitant Administration of Progesterone and Erythropoietin. Shefaye Khatam. 2014; 2 (S3) :108-108
URL: http://shefayekhatam.ir/article-1-569-en.html


Volume 2 - The Autumn Supplement of Shefaye Khatam 3 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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