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:: Volume 2, Issue 1 (Winter - 2014) ::
Shefaye Khatam 2014, 2(1): 56-62 Back to browse issues page
Assessment of AMPA Receptor Antagonist Administration on Spatial Memory of Juvenile Rats Induced Repetitive Spreading Depression
Ahmad Ali Lotfinia , Mahmud Lotfinia , Milad Ahmadi , Babak Khodaie , Maryam Jafarian *
Shefa Neuroscience Research Center, Khatam-al-Anbia Hospital, Tehran, Iran , jafarian.m34@gmail.com
Abstract:   (11448 Views)

Introduction: Spreading depression (SD) is a bio-electrical wave in the central nervous system which propagates through the gray matter and cause several effects, such as neural depolarization and ionic disturbances. This phenomenon plays a role in many neurological disorders, like epilepsy, migraine with aura, brain injury and cerebrovascular disease. The SD excitatory effect of glutamate receptors on the brain seems to be correlated with neural injuries. The aim of our study was to evaluate the role of glutamate AMPA subreceptors on spatial memory impairment induced by SD. Materials and Methods: DNQX, an AMPA antagonist, was administrated (1 mg/kg) intraperitoneally after SD induction (induced by application of 2 M KCl) in juvenile wistar rats (60-80 gr). Retrieval of spatial memory was evaluated by T-maze memory test. Results: Repetitive weekly induction of SD caused memory impairment after four weeks. Blockade of AMPA receptors with DNQX did not affect the memory impairment caused by SD. Conclusion: Our data indicate glutamate AMPA subreceptors are not involved in SD-induced memory deficits in juvenile rats.

Keywords: Cortical Spreading Depression, Receptors, AMPA, Memory
Full-Text [PDF 615 kb]   (2645 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neurophysiopathology



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Lotfinia A A, Lotfinia M, Ahmadi M, Khodaie B, Jafarian M. Assessment of AMPA Receptor Antagonist Administration on Spatial Memory of Juvenile Rats Induced Repetitive Spreading Depression . Shefaye Khatam 2014; 2 (1) :56-62
URL: http://shefayekhatam.ir/article-1-63-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 2, Issue 1 (Winter - 2014) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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