[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Home::
Journal Information::
Articles Archive::
Guide for Authors::
For Reviewers::
Ethical Statements::
Registration::
Site Facilities::
Contact us::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Copyright Policies

 

AWT IMAGE

 

..
Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

..
:: Volume 3, Issue 1 (Winter - 2015) ::
Shefaye Khatam 2015, 3(1): 71-78 Back to browse issues page
Effect of Nettle Root Extract on Histometrical Parameters of Cerebral and Cerebellar Cortices in Rat Following Administration of Testosterone
Sajad Sahab Negah , Zabihollah Khaksar , Shahin Mohammad Sadeghi , Naeem Erfanimajd , Mostafa Modarres Mousavi , Hadi Aligholi , Masoud Adibmoradi , Hamid Reza Moradi *
Department of Basic Sciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran. , hmoradi20@yahoo.com
Abstract:   (10586 Views)

Introduction: Testosterone is a steroid hormone secreted by gonads and adrenal glands. High dose of testosterone leads to decrease neurogenesis and induce apoptosis in vitro. To modulate testosterone effect, plants contain anti-androgenic properties can be useful. Urtica dioica, often called common nettle, contains anti-androgen compounds. Furthermore, the phytoestrogens effects of nettle have been evaluated. In this study, the effect of nettle root extract on histological structures of the cerebral and cerebellar cortices of rats was evaluated after testosterone injection. Materials and Methods: Twenty healthy adult male Wistar rats were divided randomly into 4 groups: control group (received ordinary feed without any treatment), testosterone group (received 10 mg/kg testosterone subcutaneously), nettle root extract group (received 50 mg/kg nettle root extract orally), nettle + testosterone group (received 50 mg/kg orally nettle root extract and 10 mg/kg testosterone). After 6 weeks, the brains were stained by hematoxylin and eosin. The number of neuronal cell body, nuclear diameter of neurons, diameter of Purkinje cells, and diameter of cerebellar layers were measured. Results: There were no significant differences in the mean number of neuronal cell body in cerebral cortex, diameter of Purkinje cells in cerebellum, and thickness of cerebellar layers among different groups. The nuclear diameter of neurons in inner granular layer of cerebrum in the testosterone group significantly increased compared to the nettle and nettle + testosterone groups. Conclusion: Nettle plant can be considered as a testosterone modulator. To determine more precise effect of nettle on the brain, further studies are needed.

Keywords: Brain, Rats, Urtica dioica, Testosterone
Full-Text [PDF 1608 kb]   (4130 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neuropharmacology



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sahab Negah S, Khaksar Z, Mohammad Sadeghi S, Erfanimajd N, Modarres Mousavi M, Aligholi H, et al . Effect of Nettle Root Extract on Histometrical Parameters of Cerebral and Cerebellar Cortices in Rat Following Administration of Testosterone. Shefaye Khatam 2015; 3 (1) :71-78
URL: http://shefayekhatam.ir/article-1-659-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 3, Issue 1 (Winter - 2015) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.05 seconds with 45 queries by YEKTAWEB 4660