Introduction: Brain injury is one of the main concerns in societies and a leading cause of death and disability worldwide. Following a brain injury, primary and secondary injuries occur and cause a complicated pathological process. Experimental brain injury models can be divided into focal brain injury models, diffused brain injury models, models used in tissue engineering strategies, and in vitro models of brain injury. Conclusion: By choosing a proper experimental model, we can address the pathology of brain injury and assess the potential treatments.