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:: Volume 2, Issue 2 (Spring - 2014) ::
Shefaye Khatam 2014, 2(2): 41-46 Back to browse issues page
Investigation on the Motor Recovery Effect of a Self-Assembling Nanofiber in the Spinal Cord Injury Model in Rat
Shima Tavakol, Hadi Aligholi, Arezou Eshaghabadi, Mostafa Modarres Mousavi, Jafar Ai, Mehdi Rezayat *
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. , Rezayat@tums.ac.ir
Abstract:   (10400 Views)

Introduction: Spinal cord injury (SCI) is a serious disabling condition associated with paralysis. Owing to suitable effects of hydrogels compared to preformed scaffolds, in this study a hydrogel based biomaterial, Matrigel, was applied. Matrigel is a termogel that forms nanofibers and hydrogel above 20°C. It contains laminin, nidogen and some growth factors that induce neural differentiation. Materials and Methods: A moderate spinal cord contusion was performed in adult rats and 10 days after injury, matrigel was implanted. Then, they follow up via Basso, Beattie, Bresnahan test for 42 days. Cresyl violet staining was performed as a histopatological analysis. Results: Our data indicated less inflammation and dark cells in Matrigel group compared to control group. Locomotor test showed significant improvement of motor recovery in Matrigel group. Conclusion: Our results suggest that Matrigel via some growth factors and adhesive molecules may have beneficial effects on functional recovery in SCI.

Keywords: Spinal Cord Injuries, Hydrogels, Laminin, Tissue Scaffolds
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Tavakol S, Aligholi H, Eshaghabadi A, Modarres Mousavi M, Ai J, Rezayat M. Investigation on the Motor Recovery Effect of a Self-Assembling Nanofiber in the Spinal Cord Injury Model in Rat. Shefaye Khatam. 2014; 2 (2) :41-46
URL: http://shefayekhatam.ir/article-1-79-en.html

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Volume 2, Issue 2 (Spring - 2014) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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