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:: Volume 2, Issue 2 (Spring - 2014) ::
Shefaye Khatam 2014, 2(2): 13-20 Back to browse issues page
Evaluation of Apoptosis in Rat Hippocampal Tissue in an Experimental Model of Alzheimer's Disease
Fatemeh Alipour , Elham Mohammadzadeh *, Behzad Khallaghi
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b.Biology and Anatomical Science Department, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , elhammohammadzadeh85@gmail.com
Abstract:   (3826 Views)

Introduction: Apoptosis plays a crucial role in normal development of central nervous system. In fact, disregulation of apoptosis is the major pathophysiological mechanism of many diseases, such as Alzheimer's disease. The aim of this survey was to study the role of apoptosis in neuronal injury during Alzheimer's disease. Materials and Methods: The experiments were carried out in adult (6-7 months old) male Wistar rats (230-270 g) in 2 groups of sham and streptozocin (STZ). Animals in sham and STZ groups received normal saline and STZ intracerebroventricular (ICV) injections for two days, respectively. To assess neuronal apoptosis, 18, 45 and 90 days after STZ injection, TUNEL test was performed. Results: The result showed that apoptosis in hippocampal CA1 and CA3 areas were significantly increased in rats treated with STZ after 90 days. Also, there was a significant increase in the mean number of apoptotic cells in rats treated with STZ after 90 days compared to their age-matched sham group in the hippocampal CA1 and CA3 area. Conclusion: ICV-STZ injection in rats was resulted in significant neuronal apoptosis in the hippocampus.

Keywords: Alzheimer Disease, Apoptosis, Streptozocin, Rats
Full-Text [PDF 1929 kb]   (2463 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience



DOI: 10.18869/acadpub.shefa.2.2.13


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Alipour F, Mohammadzadeh E, Khallaghi B. Evaluation of Apoptosis in Rat Hippocampal Tissue in an Experimental Model of Alzheimer's Disease. Shefaye Khatam. 2014; 2 (2) :13-20
URL: http://shefayekhatam.ir/article-1-85-en.html
Volume 2, Issue 2 (Spring - 2014) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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