[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Home::
Journal Information::
Articles Archive::
Guide for Authors::
For Reviewers::
Ethical Statements::
Registration::
Site Facilities::
Contact us::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Copyright Policies

 

AWT IMAGE

 

..
Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

..
:: Volume 4, Issue 3 (Summer - 2016) ::
Shefaye Khatam 2016, 4(3): 91-102 Back to browse issues page
Parkinson Disease: from Pathophysiology to the Animal Models
Somayeh Vazifehkhah , Fariba Karimzadeh *
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran , Fariba_karimzade@yahoo.com
Abstract:   (8200 Views)

Introduction: Parkinson disease (PD) is a severe and progressive neurodegenerative disorder in the central nervous system. The most features of this disease are several parts-substantia nigra compacta cell-loss, and accumulation of aggregated α-synuclein in specific brain stem, spinal cord, and cortical regions. The main risk factors are age and environmental factors. Several genes have been identified for inheritance PD. Identification of these genes had been leaded to provide new solutions. Dopamine replacement therapy and commonly used drugs significantly reduce motor handicaps and had a positive effect on the quality of life improvement. Animal models are important in investigation of the mechanisms involved in the pathogenesis of PD and therapeutic strategies. Conclusion: Despite numerous models to induce PD, MPTP and 6-OHDA models have been more frequently used. In this study, the most important factors involved in the pathophysiology of PD as well as the most current animal models, are described.

Keywords: Parkinson Disease, Animals, Dopaminergic Neurons, Levodopa
Full-Text [PDF 484 kb]   (21540 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Neurology



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Vazifehkhah S, Karimzadeh F. Parkinson Disease: from Pathophysiology to the Animal Models. Shefaye Khatam 2016; 4 (3) :91-102
URL: http://shefayekhatam.ir/article-1-969-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 4, Issue 3 (Summer - 2016) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.05 seconds with 45 queries by YEKTAWEB 4645