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:: Volume 4, Number 4 (2016) ::
Back to browse issues page Shefaye Khatam 2016, 4(4): 35-40
The Effect of Trichostatin A on Working Memory and Serum Bcl-2 Level in Hypoxic-Ischemia Rat Model
Zahra Kahvand, Mohammad Amin Edalatmanesh *
Department of Physiology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran , amin.edalatmanesh@gmail.com
Abstract:   (482 Views)

Introduction: Cerebral ischemia, occurs when a blood clot has occluded a brain artery, is the third leading cause of mortality in the Western world. The present study was aimed to investigate the effects of Trichostatin A (TSA), a histone deacetylase inhibitor, on cognitive deficits and serum Bcl-2 level in an animal model of hypoxia-ischemia rat model (HI). Materials and Methods: Thirty male Sprague dawley rats were randomly divided into the healthy control, HI+Saline and HI+TSA groups. The rats were suffered from the right common carotid artery ligation and 8% oxygen for 5 min to produce HI model. Two days after induction of ischemia, HI+TSA group received intraperitoneally TSA for 5 days. The Y maze test was used to assess the working memory. The ELISA test was performed to measure the serum Bcl-2 level. Results: The results showed amelioration of working memory in HI+TSA group compared to HI+Saline rats. In addition, a significant difference in the serum level of Bcl-2 was observed between HI+TSA and HI+Saline groups. Conclusion: The data suggested TSA as a potential treatment for amelioration of cognitive deficits after brain ischemia.

Keywords: Hypoxia, Brain, Ischemia, trichostatin A
Full-Text [PDF 468 kb]   (230 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Molecular Neurobiology



DOI: 10.18869/acadpub.shefa.4.4.35


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Kahvand Z, Edalatmanesh M A. The Effect of Trichostatin A on Working Memory and Serum Bcl-2 Level in Hypoxic-Ischemia Rat Model. Shefaye Khatam. 2016; 4 (4) :35-40
URL: http://shefayekhatam.ir/article-1-984-en.html
Back to browse issues page Volume 4, Number 4 (2016)
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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