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Showing 2 results for Baradaran
Saeideh Baradaran, Akbar Hajizadeh Moghaddam, Maryam Ghasemi-Kasman,
Volume 6, Issue 2 (The Spring Supplement of Shefaye Khatam 1 - 2018)
Abstract
Multiple sclerosis (MS) is one of the most autoimmune neurological and inflammatory disease in worldwide. Demyelination and disturbance of action potential conductance are regarded as main signs of MS disease. Hesperetin (Hst) is one of the flavonoid that have neuroprotective properties. The present study attempts to evaluate the effects of hesperetin or its nanoparticle on myelin repair and glial activation in lysolecithin (LPC) -induced demyelination model. Local demyelination was induced by administration of LPC (1%, 2μL) into the rat' optic chiasm. Animals have received oral administration of Hst or nano-Hst at dose of 20 mg/kg for 14 and 21 days post lesion. Visual evoked potential (VEPs) records were performed on days 0, 7, 14 and 21 post lesions. Immunostaining against Iba 1 (microglia marker) and GFAP (astrocytes marker) were carried out for evaluation of myelination and astrocytes activation. Electrophysiological evidence emphasize that oral administration of hesperetin and nano-hespretin could reduce the P1-N1 latency and increase the amplitude of VEPs waves compared to the saline and Hst groups (p≤0.001). Immunostaining showed that myelin repair was improved in animals which have received nano-Hst treatment; In addition, nano-hesperetin and its nanoparticle effectively reduced the expression of GFAP in optic chiasm (p≤0.001). The extent of demyelination was reduced in animals under treatment of hesperetin) p≤0.01 (or nanohesperetin(p≤0.001). Our results showed hesperetin and nano-hesperetin treatment significantly enhances myelin restoration through endogenous sources of glial progenitor cells following local injection of LPC.
Saeideh Baradaran, Akbar Hajizadeh Moghaddam, Sedigheh Khanjani Jelodar,
Volume 6, Issue 2 (The Spring Supplement of Shefaye Khatam 1 - 2018)
Abstract
Inflammatory disorders alone or as a consequence of neurological disease affecting patients in life. Experimental models of inflammation are use to evaluate the production of inflammatory mediators at site of inflammation. Curcumin is one of the flavonoids possesses potent anti-inflammatory activity. However, because of low water solubility curcumin, its clinical application has been limited. The present study attempts to assessment the effects of curcumin and nano-phytosome of curcumin on improve of behavioral impairment and reduce inflammation cytokines in carrageenan-induced inflammation model. Animals have received oral administration of curcumin or nano-phytosom of curcumin at dose of 15 mg/kg for 7 days before injection of carrageenan. Acute inflammation was induced by injection of carrageenan (1%,) into the subplantar region of left paw in mice. Tail pinch test and hotplate test (for evaluated the threshold of neuroinflammation pain) were performed on ½ h before injection and ½ h, 2 h, 24 h after injection of carrageenan. The results of behavioral testes showed enhance of antinociceptive effects in the animals recieved curcumin(p≤0.01) and nano-phytosome of curcumin (p≤0.001) compaired to other groups. These results suggested that curcumin and its nano-phytosome improvement behavioral impairment and reduce inflammation cytokines following local injection of carrageenan.
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