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Showing 2 results for Gashmardi
Noushin Gashmardi, Mohammad Amin Edalatmanesh,
Volume 5, Issue 3 (Summer - 2017)
Abstract
Introduction: Spinal cord injury (SCI) is a nervous system disorder that often results in loss of motor, sensory, and autonomic functions. There is no definite treatment for SCI. However, cell replacement therapy has shown the potential for the spinal cord repair in SCI animal models. Different types of stem cells, such as mesenchymal and neural stem cells, were utilized for cell therapy in SCI. Stem cells achieved through trophic and immunomodulatory factors. These cells can provide appropriate microenvironment for axon regeneration. Conclusion: Stem cell therapy in SCI lead to reduce the acute inflammatory responses and improve the motor function. Cell therapy is a promising strategy in the treatment of SCI. However, clinical trials are needed to test the efficacy and safety of this treatment.
Noushin Gashmardi, Mohammad Amin Edalatmanesh,
Volume 7, Issue 4 (Autumn 2019)
Abstract
Introduction: Spinal cord injury (SCI) following traumatic events is associated with the limited therapeutic options and sever complications, which can be partly due to inflammatory response. Therefore, this study aims to explore the role of inflammation in spinal cord injury. The findings showed that the pathological conditions of nervous system lead to activation of microglia, astrocyte, neutrophil, and macrophages. It is also may be mediated by glial and lead to neuronal injury and death through production of proinflammatory factors, such as cytokines (key factors in the onset, progression and suppression of inflammation) and chemokines. Inflammation is a major component of spinal cord injury; although it is possible that inflammation has beneficial effects, such as phagocytosis of apoptotic cells and pathogens clearance. However, this could contribute to spreading, amplifying, and chronicity of tissue damage, via production of neurotoxic factors. Conclusion: It seems that inflammation has a major role in the injured spinal cord. Identifying effective cells in the inflammatory responses as well as their numbers, nature of their actions, and types of released inflammatory factors, along with the discovery of appropriate coping strategies against them, will increase the hope to repair spinal cord injuries in future.
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