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Showing 5 results for Togha

Amir Ghaemi , Shahnaz Babaei Abraki, Sedigheh Ghasemi , Azadeh Sajadian, Mansoureh Togha,
Volume 2, Issue 4 (Autumn - 2014)
Abstract

Introduction: Multiple sclerosis (MS) is an autoimmune disease of central nervous system that is characterized by the progressive loss of myelin. In addition to immunoregulatory properties, novel MS therapies promote myelin repair activities. Mesenchymal stem cells (MSCs) have been viewed as a potent tool for regenerative and immunosuppressive functions, indicating a potential therapy for MS. MSCs have immunological functions which are exerted by direct cell-to-cell contacts, secretion of stimulatory and inhibitory cytokines, and/or a combination of both mechanisms. Therefore, these cells can inhibit differentiation and proliferation of T-cell and stimulate the Th2 and regulatory T-cells through inhibitory effects on the immune system. Conclusion: In the current review, we discuss the mechanisms underlying the immunomodulatory effect of MSCs in different experimental models of MS.


Maryam Abolhasani, Soodeh Razeghi Jahromi, Mansoureh Togha, Mohammad Ali Sahraian, Solmaz Sadr-Jahani,
Volume 2, Issue 4 (Autumn - 2014)
Abstract

Introduction: Fatigue is considered to be one of the main causes of im‌paired quality of life among patients with multiple sclerosis (MS). Creatine enhances ATP synthesis and possesses antioxidant properties. There has been interest in the use of creatine supplement for fatigue and muscle strength in neurological disorders. It has previously been reported that, using 20 gram/day creatine supplement for 5-7 days followed by 5 gram/day for another 7 days did not ameliorate fatigue in patients with MS. In this study, we aimed to determine whether longer application of creatine supplement would be effective in controlling fatigue in these patients. Materials and Methods: In a double-blind controlled trial, 20 patients with MS with fatigue and mild to moderate disability were randomly assigned to creatine (10 gram, two times a day for 14 days) and placebo (10 patients in each group). Fatigue was assessed at baseline and after 14 days using fatigue severity scale (FSS). Results: No significant differences were observed between FSS score before and after the intervention. Furthermore, no significant difference was observed between the experimental groups in the mean difference of FSS. Conclusion: Creatine supplementation had no significant effect on fatigue score even after longer administration.


Leila Zareian, Leila Rohi, Mansoureh Togha,
Volume 4, Issue 4 (Autumn - 2016)
Abstract

Introduction: Traumatic brain injury is the leading cause of death and disability in young adults. Green tea Epigallocatechin-3-gallate (EGCG) supplementation favorably influenced many of the processes mention in the secondary insult of brain injury, including neuroinflammation and anti-oxidative damages in animal studies. In current study, we aimed to investigate the effect of EGCG on outcomes of traumatic brain injury. Materials and Methods: In a clinical trial, 30 patients with head trauma hospitalized in the intensive care unit of Sina hospital, Tehran, Iran were randomly divided into two groups. These groups included 15 patients who received a single daily oral dose of EGCG (400 mg) for 7 days and control group of 15 patients received placebo (distilled water) for the same period. Protein level S100 B and GCS were investigated between the two groups. Results: EGCG increased Glasgow coma score scale. However EGCG had no significant effect on the level of protein S100B. Conclusion: EGCG may play a neuroprotective effect in trumatic brain insulats.


Fariba Ebrahimi, Fatemeh Najmi Varzaneh, Younes Mohammadi, Soodeh Razaghi Jahromi, Farnaz Najmi Varzaneh, Mansoureh Togha,
Volume 6, Issue 2 (Spring - 2018)
Abstract

Introduction: Headache is one of the most common pain syndromes in humans, which can lead to social and occupational dysfunctions. The aim of this study was to investigate the prevalence of migraine and tension type headache (TTH) among the staffs of Sina Hospital, Tehran, Iran and its relationship with socio-demographic variables as well as psychological factors. Materials and Methods: This analytical observational study was conducted in 590 employees of Sina Hospital in Tehran, Iran using a randomized sampling method. The prevalence of migraine and TTH was evaluated in relation to psychological and socio-demographic variables. Required information was collected through a questionnaire and the diagnosis of the type of headache was confirmed by a neurologist. Results: The total prevalence of headaches within our study population was 129 cases among 590 subjects (21.8%), of which 58 (9.8%) subjects were migraineurs, 67 (11.3%) subjects had TTH, and 4 (0.67%) people had both TTH and migraine. These headaches were significantly higher in nurses, staffs with a bachelor's degree or above, staffs with an average daily working hours of more than 8 hours, and staffs working in the morning shift. TTH had also a significant relationship with psychological characteristics, such as depression, fatigue, and job dissatisfaction. Job absenteeism, referral to physicians, and inability to do routine works during their headache periods were significantly higher in staffs with migraine headaches compared to TTH. Conclusion: TTH and migraine headaches had a significant relationship with the type of job, educational levels, and type of work shifts. In addition, migraine headaches had more negative effects on the quality of work compared to TTH.


Shiva Nematgorgani, Zahra Gholi, Soodeh Razeghi Jahromi, Mansoureh Togha, Fariba Karimzadeh,
Volume 8, Issue 2 (Spring 2020)
Abstract

Introduction: Migraine is a common, painful and potentially debilitating disease that is characterized by frequent, unilateral, pulsating attacks of moderate to severe severity. The main cause of migraine is unknown. It seems the B vitamins affect clinical symptoms of the migraine headache. In this study, we reviewed the effects of some vitamins B on improving the symptoms of migraine headaches and their possible mechanism of action. In this study, we evaluated the articles published between 2002 and 2018 on this topic in Scopus, Science Direct, PubMed, and Google Scholar. Conclusion: The findings of several studies suggest that some of vitamins B can improve migraine headaches, particularly their frequency and severity. Dietary supplementation of vitamins B could efficiently prevent or alleviate different symptoms of the migraine headache.

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مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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