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Introduction: Caloric restriction (CR) has been considered as a kind of diet therapy for some neurological diseases. This study was aimed to investigate the effect of CR on the seizure behavior induced in rats. Materials & Methods: CR was applied with deprivation of food and water for 24 hours every other day for a period of four weeks. Seizure induced by pentylenetetrazol (PTZ) injection. Animals in CR1 group were accessed caloric restriction before PTZ injection. Animals in CR2 group were accessed caloric restriction after PTZ injection. Animals in CR3 group were accessed caloric restriction before and after PTZ injection. Results: The scores of seizure behaviors were significantly decreased in groups of animals that received CR before PTZ injection. Conclusion: These findings suggest the CR reduces scores of seizure behaviour and may be helpful in the refractory epilepsy.

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Introduction: Parkinson's disease (PD), a degenerative disorder commonly affects the extrapyramidal system, is the second most common neurodegenerative disorder after Alzheimer's disease. It has been shown that caloric restriction increases life expectancy, decreases the incidence of several age-related diseases, and preserves youth activities in a large scale of laboratory animals. Several studies have revealed that exercise may have neuroprotective effects and increase neurogenesis and angiogenesis. Therefore, the aim of this study was to investigate the effect of caloric restriction diet on reserpine-induced catalepsy in a rat model of PD. Materials and Methods: 54 Wistar male rats were divided into 9 groups (control, exercise, PD, caloric restriction, PD + exercise, caloric restriction + exercise, PD + caloric restriction, caloric restriction+ PD II, and PD + exercise +caloric restriction). PD was induced by administration of reserpine (1 mg/kg, i.p). The bar- test was used to measure cataleptic symptoms. All animals in the Exercise group were forced to run on a motorized treadmill (24 m/min for 20 min, 5 days/week) for 3weeks. Animals in the caloric restriction groups were under 30% caloric restriction diets. Results: Catalepsy was significantly lower in the caloric restriction + PD and PD + exercise groups than in the PD group. Furthermore, there was a significant decrease in catalepsy was observed in the PD + exercise +caloric restriction group compared to the PD. Conclusion: Caloric restriction of 30 percent and treadmill exercise can improve reserpine-induced catalepsy in an animal model of PD. In addition, application of caloric restriction before induction of PD may reduce the severity of complications in PD, including catalepsy.