TY - JOUR T1 - Laminin Position as One of the Important Components of the Extracellular Matrix in Tissue Engineering of Nervous System TT - جایگاه لامینین به عنوان یکی از اجزای مهم ماتریکس خارج سلولی در مهندسی بافت سیستم عصبی JF - The-Neuroscience-Journal-of-Shefaye-Khatam JO - The-Neuroscience-Journal-of-Shefaye-Khatam VL - 2 IS - 1 UR - http://shefayekhatam.ir/article-1-65-en.html Y1 - 2014 SP - 69 EP - 74 KW - Laminin KW - Extracellular Matrix KW - Tissue Engineering KW - Nervous System N2 - Introduction: Brain damage is often irreversible due to poor brain's self-repairing ability. New treatment strategies focused on stem cell therapy and 3-dimension matrix for brain tissue injury. The extracellular matrix (ECM) of animal tissues is a complex mixture of macromolecules that play an essential instructional role in the development of tissues and organs. Therefore, tissue engineering approaches rely on the need to present the correct cues to cells and to guide them to maintain tissue-specific functions. Recent research efforts on ECM have showed various sequences and motifs, which play key roles in improvement of the brain function after injury. Conclusion: Small motif from ECM molecules can mimic some of the biological functions of their large molecules. Peptides sequences and motifs laminin can be linked to various biomaterials scaffolds and provide the cells with mechanical support. This may ensure appropriate cell growth that aids the formation of the correct tissue structure. M3 10.18869/acadpub.shefa.2.1.69 ER -